Galectin-8 改变免疫微环境并促进肿瘤进展。,American journal of cancer research

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Galectin-8 改变免疫微环境并促进肿瘤进展。
American journal of cancer research Pub Date : 2023-06-15
Yiting Wang _{1,

2} , Yufan Sun ₃ , Hai Li ₁ , Jie Xu ₂

Affiliation

Galectin-8 (Gal-8) 由 LGALS8 基因编码，是 Galectin 家族的独特成员，具有多种生物学功能，包括肿瘤调节能力。最近，越来越多的证据支持 Gal-8 在调节先天性和适应性免疫中发挥重要作用，在肿瘤和其他免疫失调疾病中高表达。本研究通过分析肿瘤浸润细胞的动物模型和临床数据，揭示了 Gal-8 诱导的肿瘤免疫抑制的作用。在表达 Gal-8 的肿瘤中，我们发现抑制性免疫细胞（包括 Tregs 和 MDSC）扩增，而 CD8+ 细胞减少，这提供了 Gal-8 调节肿瘤免疫微环境的直接证据。此外，我们不仅分析了乳腺癌和结直肠癌临床样本中 Gal-8 的表达，还对组织表达模式进行了分类。进一步分析表明 Gal-8 与淋巴结转移和免疫表型相关。与动物实验一致，我们对 LGALS8 基因表达的分析表明，其与癌症中浸润的活性 CD8+ T 细胞和免疫刺激调节剂呈负相关。我们的研究确定了 Gal-8 的潜在预后和治疗价值，并等待进一步研究开发相应的靶向治疗策略。我们对 LGALS8 基因表达的分析表明，其与癌症中浸润的活性 CD8+ T 细胞和免疫刺激调节剂呈负相关。我们的研究确定了 Gal-8 的潜在预后和治疗价值，并等待进一步研究开发相应的靶向治疗策略。我们对 LGALS8 基因表达的分析表明，其与癌症中浸润的活性 CD8+ T 细胞和免疫刺激调节剂呈负相关。我们的研究确定了 Gal-8 的潜在预后和治疗价值，并等待进一步研究开发相应的靶向治疗策略。

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Galectin-8 alters immune microenvironment and promotes tumor progression.

Galectin-8 (Gal-8), encoded by LGALS8 gene, is a unique member of the Galectin family with diverse biological functions, including tumor-modulating capabilities. Recently, evidence has accumulated supporting an essential role for Gal-8 in regulating innate and adaptive immunity, with high expression in tumors and other immune dysregulation diseases. This study reveals the role of Gal-8-induced tumor immunosuppression by analyzing animal models and clinical data of tumor-infiltrating cells. In Gal-8 expressing tumor, we found that suppressive immune cells, including Tregs and MDSCs, expanded while CD8+ cells decreased, providing direct evidence that Gal-8 regulates the tumor immune microenvironment. In addition, we not only analyzed the expression of Gal-8 in clinical samples of breast and colorectal cancer but also classified the tissue expression patterns. Further analysis revealed that Gal-8 correlates with lymph node metastasis and immunophenotyping. Consistent with animal experiments, our analysis of LGALS8 gene expression showed its negative association with infiltrated active CD8+ T cells and immune stimulatory modulators in cancers. Our study identified the potential prognostic and therapeutic value of Gal-8, and further research on developing corresponding targeted therapeutic strategies is awaited.

更新日期：2023-06-15

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