Diphenyl ethers (DPEs) are mainly produced by microorganisms and plants. The chemical structure of DPEs is relatively simple, and all of these compounds have the structure of biphenyl ethers in their chemical structure, the difference being the difference in the substituents on the benzene ring. Several recent studies have shown antibacterial, antioxidant, antitumor, antitumor, antihemolytic, neuroprotective, and anti-Alzheimer effects. DPEs could be candidate compounds for the treatment of Alzheimer's disease, by inhibiting the aggregation of Aβ42. Many DPEs from natural products exhibit good biological activity and they play an important role in the control of microbial infections. Diphenyl ethers have a wide range of applications and research value in the fields of pesticides, pharmaceuticals, textiles, household products, and public health. In this paper, we review the research progress of diphenyl ethers isolated from marine and plant endophytic sources in recent years, including their biosynthesis, and lay the foundation for further utilization and development.

中文翻译：

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二苯醚：分离、生物活性和生物合成

二苯醚（DPE）主要由微生物和植物产生。DPEs的化学结构比较简单，这些化合物的化学结构均具有联苯醚结构，区别在于苯环上的取代基不同。最近的几项研究表明，其具有抗菌、抗氧化、抗肿瘤、抗肿瘤、抗溶血、神经保护和抗阿尔茨海默病等作用。DPEs 可能是通过抑制 Aβ42 聚集来治疗阿尔茨海默病的候选化合物。许多来自天然产物的DPE表现出良好的生物活性，在控制微生物感染方面发挥着重要作用。二苯醚在农药、医药、纺织、家居用品、公共卫生等领域具有广泛的应用和研究价值。本文综述了近年来从海洋和植物内生来源分离的二苯醚及其生物合成的研究进展，为进一步利用和开发奠定基础。