NiCo LDH纳米酶对革兰氏阴性菌具有选择性抗菌活性，有助于伤口愈合,Journal of Materials Chemistry B

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NiCo LDH纳米酶对革兰氏阴性菌具有选择性抗菌活性，有助于伤口愈合
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-07-11 , DOI: 10.1039/d3tb00957b
Li Su ₁ , Sainan Qin ₁ , Xinai Yu ₁ , Yifei Chen ₁ , Liang Wang ₁ , Wenpei Dong ₁ , Zhongjian Xie _{2,

3} , Han Zhang ₄

Affiliation

细菌感染已成为人类健康的主要威胁。特别是，革兰氏阴性（G ^-）细菌感染已成为世界范围内日益严重的问题。抗生素的过度使用会导致耐药性的出现，因此开发新型抗菌药物非常重要，特别是针对G-^细菌。纳米酶利用活性氧（ROS）来杀死细菌，降低细菌耐药性的风险，并为应对菌株选择性的挑战提供新的机会。在这里，我们合成了 NiCo 层状双氢氧化物 (LDH) 纳米酶，它基于其类过氧化物 (POD 类) 活性而表现出选择性抗菌活性。为了获得最高的抗菌活性，通过调整镍和钴的比例进一步优化NiCo LDH纳米酶的类POD活性，并且Ni ₄ Co ₆ LDH表现出最高的POD活性和抗菌活性。更重要的是，Ni ₄ Co ₆ LDHs由于其静电吸附和与细菌细胞壁的亲水相互作用，可以实现对G-细菌^的选择性灭菌。^{动物实验进一步表明， G-}菌感染伤口的愈合得到有效促进，且不损伤其正常生物组织。总之，我们通过简单的策略提供了一种选择性抗菌剂，为纳米酶的应用提供了新的方向。

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NiCo LDH nanozymes with selective antibacterial activity against Gram-negative bacteria for wound healing

Bacterial infections have been a major threat to human health. Especially, Gram-negative (G⁻) bacterial infections have been an increasing problem worldwide. The overuse of antibiotics leads to an emergence of drug resistance, and thus the development of novel antimicrobial agents is important, particularly against G⁻ bacteria. Nanozymes use reactive oxygen species (ROS) to kill bacteria, reducing the risk of bacterial resistance and providing new opportunities to meet the challenges of strain selectivity. Here, we synthesized NiCo layered double hydroxide (LDH) nanozymes, which exhibit selective antibacterial activity based on their peroxide-like (POD-like) activity. To obtain the highest antibacterial activity, the POD-like activity of NiCo LDH nanozyme was further optimized by tuning the ratio of nickel and cobalt, and Ni₄Co₆ LDHs showed the highest POD activity and antibacterial activity. More importantly, Ni₄Co₆ LDHs can achieve selective sterilization of G⁻ bacteria due to their electrostatic adsorption and hydrophilic interactions with the bacterial cell wall. Animal experiments further indicated that the healing of G⁻ bacteria-infected wounds was effectively promoted without damaging their normal biological tissues. In conclusion, we provide a selective antibacterial agent through a simple strategy, which provides a new direction for the application of nanozymes.

更新日期：2023-07-11

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