<br>NAD 代谢：在衰老调节和衰老中的作用,Aging Cell

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NAD 代谢：在衰老调节和衰老中的作用
Aging Cell ( IF 8.0 ) Pub Date : 2023-07-09 , DOI: 10.1111/acel.13920
Claudia Christiano Silva Chini _{1,

2} , Heidi Soares Cordeiro _{1,

2} , Ngan Le Kim Tran ₃ , Eduardo Nunes Chini _{1,

2}

Affiliation

老年科学假说提出，解决衰老的生物学问题可以直接预防多种慢性疾病的发作或减轻其严重程度。了解衰老生物学特征的关键方面之间的相互作用对于实现老年科学假说的承诺至关重要。值得注意的是，核苷酸烟酰胺腺嘌呤二核苷酸 (NAD) 与衰老的几个生物学标志有关，包括细胞衰老，并且 NAD 代谢的变化已被证明与衰老过程有关。 NAD 代谢与细胞衰老之间的关系似乎很复杂。一方面，低NAD ⁺引起的DNA损伤累积和线粒体功能障碍可促进衰老的发生。另一方面，衰老过程中出现的低 NAD ⁺状态可能会抑制 SASP 的发育，因为这种分泌表型和细胞衰老的发展都对代谢有很高的要求。然而，迄今为止，NAD ⁺代谢对细胞衰老表型进展的影响尚未得到充分表征。因此，为了探索 NAD 代谢和 NAD 替代疗法的影响，有必要考虑它们与其他衰老标志（包括细胞衰老）的相互作用。我们认为，全面了解 NAD 增强策略和 senolytic 药物之间的相互作用对于推进该领域是必要的。

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NAD metabolism: Role in senescence regulation and aging

The geroscience hypothesis proposes that addressing the biology of aging could directly prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the interplay between key aspects of the biological hallmarks of aging is essential in delivering the promises of the geroscience hypothesis. Notably, the nucleotide nicotinamide adenine dinucleotide (NAD) interfaces with several biological hallmarks of aging, including cellular senescence, and changes in NAD metabolism have been shown to be involved in the aging process. The relationship between NAD metabolism and cellular senescence appears to be complex. On the one hand, the accumulation of DNA damage and mitochondrial dysfunction induced by low NAD⁺ can promote the development of senescence. On the other hand, the low NAD⁺ state that occurs during aging may inhibit SASP development as this secretory phenotype and the development of cellular senescence are both highly metabolically demanding. However, to date, the impact of NAD⁺ metabolism on the progression of the cellular senescence phenotype has not been fully characterized. Therefore, to explore the implications of NAD metabolism and NAD replacement therapies, it is essential to consider their interactions with other hallmarks of aging, including cellular senescence. We propose that a comprehensive understanding of the interplay between NAD boosting strategies and senolytic agents is necessary to advance the field.

更新日期：2023-07-09

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