The development of biocompatible delivery systems is a necessity for medical and topical applications. Herein, the development of a new bigel for topical application is described. It is composed of 40% colloidal lipid hydrogel and 60% olive oil and beeswax oleogel. Its characterization and the potential of the bigel as a drug carrier through the skin was evaluated in vitro using fluorescence microscopy and two phases of the bigel were labeled with two fluorescent probes: sodium fluorescein (hydrophilic phase) and Nile red (lipophilic phase). The structure of the bigel showed two phases with fluorescence microscopy in which the hydrogel phase was incorporated into a continuous oleogel matrix. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) presented a combination of vibrations characteristic of the different molecules forming the bigel, and Differential Scanning Calorimetry (DSC) showed different transitions attributed to beeswax lipids. Small-angle and wide-angle X-ray scattering (SAXS and WAXS) indicated a predominant lamellar structure with orthorhombic lateral packing that could be related to the arrangement of beeswax crystals. Bigel enables deeper penetration of hydrophilic and lipophilic probes into deeper layers, making it a promising candidate for effective topical carriers in medical and dermatological applications.

生物相容性输送系统的开发是医疗和局部应用的必要条件。本文描述了一种用于局部应用的新型 Bigel 的开发。它由40%胶体脂质水凝胶和60%橄榄油和蜂蜡油凝胶组成。使用荧光显微镜在体外评估了 Bigel 的表征和作为穿过皮肤的药物载体的潜力，并用两种荧光探针标记了 Bigel 的两个相：荧光素钠（亲水相）和尼罗红（亲脂相）。通过荧光显微镜观察，双凝胶的结构显示出两个相，其中水凝胶相被纳入连续的油凝胶基质中。衰减全反射傅里叶变换红外光谱 (ATR-FTIR) 呈现了形成大凝胶的不同分子的振动特征组合，差示扫描量热法 (DSC) 显示了蜂蜡脂质的不同转变。小角和广角 X 射线散射（SAXS 和 WAXS）表明主要是具有斜方横向堆积的层状结构，这可能与蜂蜡晶体的排列有关。Bigel 能够使亲水性和亲脂性探针更深入地渗透到更深层，使其成为医疗和皮肤病学应用中有效局部载体的有希望的候选者。