Identifying potential toxic organic substances in leachates from tire wear particles and their mechanisms of toxicity to Scenedesmus obliquus,Journal of Hazardous Materials

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Identifying potential toxic organic substances in leachates from tire wear particles and their mechanisms of toxicity to Scenedesmus obliquus
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2023-07-10 , DOI: 10.1016/j.jhazmat.2023.132022
Jie-Ru Jiang ₁ , Zhi-Feng Chen ₁ , Xiao-Liang Liao ₁ , Qian-Yi Liu ₁ , Jia-Ming Zhou ₁ , Shi-Ping Ou ₁ , Zongwei Cai ₂

Affiliation

Tire wear particles (TWPs) are increasingly being found in the aquatic environment. However, there is limited information available on the environmental consequences of TWP constituents that may be release into water. In this study, TWP leachate samples were obtained by immersing TWPs in ultrapure water. Using high-resolution mass spectrometry and toxicity identification, we identified potentially toxic organic substances in the TWP leachates. Additionally, we investigated their toxicity and underlying mechanisms. Through our established workflow, we structurally identified 13 substances using reference standards. The median effective concentration (EC50) of TWP leachates on Scenedesmus obliquus growth was comparable to that of simulated TWP leachates prepared with consistent concentrations of the 13 identified substances, indicating their dominance in the toxicity of TWP leachates. Among these substances, cyclic amines (EC50: 1.04–3.65 mg/L) were found to be toxic to S. obliquus. We observed significant differential metabolites in TWP leachate-exposed S. obliquus, primarily associated with linoleic acid metabolism and purine metabolism. Oxidative stress was identified as a crucial factor in algal growth inhibition. Our findings shed light on the risk posed by TWP leachable substances to aquatic organisms.

中文翻译：

鉴定轮胎磨损颗粒渗滤液中潜在有毒有机物质及其对斜生栅藻的毒性机制

水生环境中越来越多地发现轮胎磨损颗粒 (TWP)。然而，关于 TWP 成分可能释放到水中的环境后果的信息有限。在本研究中，TWP 渗滤液样品是通过将 TWP 浸入超纯水中获得的。利用高分辨率质谱和毒性鉴定，我们鉴定了 TWP 渗滤液中潜在有毒的有机物质。此外，我们还研究了它们的毒性和潜在机制。通过我们既定的工作流程，我们使用参考标准从结构上鉴定了 13 种物质。 TWP 渗滤液对斜栅藻生长的半有效浓度 (EC50) 与用一致浓度的 13 种已鉴定物质制备的模拟 TWP 渗滤液的浓度相当，表明它们在 TWP 渗滤液的毒性中占主导地位。这些物质中，环胺（EC50：1.04-3.65 mg/L）被发现对斜纹藻有毒。我们在暴露于 TWP 渗滤液的斜生藻中观察到显着的代谢差异，主要与亚油酸代谢和嘌呤代谢相关。氧化应激被认为是抑制藻类生长的关键因素。我们的研究结果揭示了 TWP 可浸出物质对水生生物造成的风险。

更新日期：2023-07-10

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