Iridium(III)-Catalyzed C–H Cyclization of Sulfoximines with Diazo Meldrum’s Acids for the Synthesis of Cyclic Sulfoximines,The Journal of Organic Chemistry

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Iridium(III)-Catalyzed C–H Cyclization of Sulfoximines with Diazo Meldrum’s Acids for the Synthesis of Cyclic Sulfoximines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-07-10 , DOI: 10.1021/acs.joc.3c00984
Gi Uk Han ₁ , Suhui Kim ₁ , Sang Hoon Han ₁ , Chanyoung Maeng ₁ , Gi Hoon Ko ₁ , Kyungsup Lee ₁ , Hee Chan Noh ₁ , Phil Ho Lee ₁

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Iridium(III)-catalyzed C–H cyclization of sulfoximines with diazo Meldrum’s acid provided cyclic sulfoximines with a carbonyl group in good to excellent yields. These compounds were easily converted into unsubstituted and arylated sulfoximines. Moreover, the vinyl triflates obtained from the cyclic sulfoximines underwent palladium(II)-catalyzed cross-coupling reactions with a variety of aryl, arylalkynyl, and heteroatom (N and S) nucleophiles, affording a wide range of monosubstituted sulfoximines in high yields.

中文翻译：

铱(III)催化亚磺酰亚胺与重氮Meldrum酸的C-H环化反应合成环状亚磺酰亚胺

铱 (III) 催化的亚砜亚胺与重氮 Meldrum 酸的 C-H 环化反应以良好至优异的收率提供了带有羰基的环状亚砜亚胺。这些化合物很容易转化为未取代的和芳基化的亚砜亚胺。此外，由环状亚砜亚胺获得的乙烯基三氟甲磺酸酯与各种芳基、芳基炔基和杂原子（N和S）亲核试剂进行钯（II）催化的交叉偶联反应，以高产率提供各种单取代亚砜亚胺。

更新日期：2023-07-10

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