基于核酸纳米材料的透皮给药系统用于皮肤光损伤治疗,Advanced Functional Materials

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基于核酸纳米材料的透皮给药系统用于皮肤光损伤治疗
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-07-09 , DOI: 10.1002/adfm.202303580
Yu Xie ₁ , Jiajun He ₁ , Songhang Li ₁ , Xingyu Chen ₁ , Tianxu Zhang ₁ , Yuxuan Zhao ₁ , Yunfeng Lin ₁ , Xiaoxiao Cai ₁

Affiliation

由紫外线 (UV) 辐射引起的皮肤光损伤是皮肤损伤的常见原因。在这项研究中，开发了一种用于局部治疗皮肤光损伤的透皮给药系统，该系统由四面体框架核酸（tFNA）和硫辛酸（LA）组成。tFNAs-LA (TLA) 纳米复合材料具有优异的生物相容性以及抗氧化、抗凋亡和抗炎能力。tFNA作为载体，促进TLA进入细胞和皮肤渗透，而负载的LA则增强抗氧化和抗炎能力。在光损伤的人真皮成纤维细胞 (HDF) 中，TLA 促进增殖和迁移，同时抑制细胞凋亡激活和活性氧产生。此外，TLA 调节细胞凋亡相关蛋白和 NF-κB 信号通路，增加细胞分泌，同时抑制光损伤 HDF 细胞的炎症反应。在体内实验中，局部应用 TLA 可促进光损伤皮肤的组织愈合，并调节炎症和胶原蛋白相关蛋白的表达。有人认为，TLA 的透皮能力可以实现皮肤光损伤的非侵入性治疗，凸显了采用基于核酸的透皮给药系统治疗皮肤病的潜力。

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A Transdermal Drug Delivery System Based on Nucleic Acid Nanomaterials for Skin Photodamage Treatment

Skin photodamage, which is induced by ultraviolet (UV) radiation, is a prevalent cause of skin damage. In this study, a transdermal drug delivery system is developed for the topical treatment of skin photodamage, which is composed of tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA). The tFNAs-LA (TLA) nanocomposite exhibits excellent biocompatibility, as well as antioxidant, anti-apoptotic, and anti-inflammatory capabilities. tFNA, as a carrier, facilitates TLA for cell entry and skin penetration, while the loaded LA enhances the antioxidant and anti-inflammatory capabilities. In photodamaged human dermal fibroblast (HDF), TLA promotes proliferation and migration while inhibiting apoptosis activation and reactive oxygen species production. Moreover, TLA modulates apoptosis-related proteins and NF-κB signaling pathways, increasing cellular secretion while suppressing inflammatory responses in photodamaged HDF cells. In the in vivo experiment, topical application of TLA promotes tissue healing in photodamaged skin, and regulates the expression of inflammation and collagen-related proteins. It is suggested that the transdermal ability of TLA enables non-invasive therapy for skin photodamage, highlighting the potential of employing nucleic acid-based transdermal drug delivery systems for skin disease.

更新日期：2023-07-09

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