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Yuexiandajisu diterpenoids from Euphorbia ebracteolata Hayata (Langdu roots): An overview
Phytochemistry ( IF 3.2 ) Pub Date : 2023-07-05 , DOI: 10.1016/j.phytochem.2023.113784
Christian Bailly 1
Affiliation  

The roots of the plant Euphorbia ebracteolata Hayata (Yue Xian Da Ji) are commonly used in traditional Chinese medicine to treat multiple diseases such as chronic liver diseases, oedema, pulmonary diseases and cancer. It is the main ingredient of the TCM called Langdu which can be prepared also from roots of E. fischeriana Steud. and occasionally from Stellera chamaejasme species. Numerous bioactive natural products have been isolated from E. ebracteolata including a large diversity of diterpenoids with anti-inflammatory and anticancer properties. One little series of compounds has been named yuexiandajisu (A, B, C, D, D1, E, F) which comprises two casbane-, one isopimarane-, two abietane-, and two rosane-type diterpenes including a dimeric molecule. The origin, structural diversity and properties of these little-known natural products is discussed here. Several of these compounds have been identified in the roots of other Euphorbia species, notably the potent phytotoxic agent yuexiandajisu C. The abietane diterpenes yuexiandajisu D-E exhibit marked anticancer properties but their mechanism of action remains unresolved. The dimeric compound, renamed yuexiandajisu D1, also exhibit anti-proliferative properties against cancer cell lines, unlike the rosane diterpene yuexiandajisu F. The structural or functional analogy with other diterpenoids is discussed.



中文翻译:

大戟(Langdu 根)中的月仙大吉苏二萜类化合物:概述

植物大戟( Euphorbia ebracteolata Hayata)的根在中药中常用来治疗多种疾病,如慢性肝病、水肿、肺部疾病和癌症。它是中药“狼毒”的主要成分,也可以从E. fischeriana Steud 的根中制备。偶尔也来自狼毒物种。已从E. ebracteolata中分离出许多生物活性天然产物,包括多种具有抗炎和抗癌特性的二萜类化合物。一小系列化合物已被命名为月仙大吉素(A、B、C、D、D1 E、F),其包含两个卡斯班-、一个异海松烷-、两个松香烷-和两个玫瑰香型二萜,包括二聚分子。本文讨论了这些鲜为人知的天然产物的起源、结构多样性和特性。其中一些化合物已在其他大戟属物种的根部中被发现,特别是强效植物毒性剂月仙大吉苏 C。松香烷二萜月仙大吉苏 DE 表现出显着的抗癌特性,但其作用机制仍未解决。与玫瑰烷二萜月仙大吉苏 F 不同,该二聚化合物更名为月仙大吉苏 D 1 ,也表现出抗癌细胞系增殖的特性。讨论了与其他二萜类化合物的结构或功能相似性。

更新日期:2023-07-08
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