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Two birds with one stone: Ratiometric sensing platform overcoming cross-interference for multiple-scenario detection and accurate discrimination of tetracycline analogs
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2023-07-07 , DOI: 10.1016/j.jhazmat.2023.132016 Weizhen Yan 1 , Wanrong Wang 1 , Guohao Zheng 1 , Wuqi Dong 2 , Ruogu Cheng 3 , Xiaofei Shang 2 , Yuechen Xu 4 , Weijun Fang 2 , Hua Wang 4 , Changlong Jiang 5 , Tingting Zhao 2
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2023-07-07 , DOI: 10.1016/j.jhazmat.2023.132016 Weizhen Yan 1 , Wanrong Wang 1 , Guohao Zheng 1 , Wuqi Dong 2 , Ruogu Cheng 3 , Xiaofei Shang 2 , Yuechen Xu 4 , Weijun Fang 2 , Hua Wang 4 , Changlong Jiang 5 , Tingting Zhao 2
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Environmental pollution caused by tetracycline antibiotics (TCs) is a major concern for public health worldwide. Trace detection and reliable discrimination of tetracycline and its analogs are consequently essential to determine the distribution characteristics of various tetracycline family members. Here, a dual-response sensor was constructed by integrating the fluorescence emission of fluorescein isothiocyanate (FITC) doped SiO2 and Eu3+ . A portable Lab-on-Paper device is further fabricated through probe immobilization, which allows convenient visual detection of tetracycline using a smartphone. In addition, for the coexistence of multiple tetracycline analogs, dimensionality reduction via principal component analysis is applied to the spectra, realizing accurate differentiation of the four most widely used tetracycline analogs (tetracycline (TC), chlortetracycline (CTC), oxytetracycline (OTC), and doxycycline (DOX)). The dual-response nanoplatform enabled a wide-gamut color variation crossing from green to red, with limit of detection (LOD) of 2.9 nM and 89.8 nM for spectrometer- and paper-based sensors, respectively. Analytical performance was examined in multiple real samples, including food, environmental, and biological settings, confirming robust environmental adaptability and resistance. Compared to previous TC sensors, this method has several notable improvements, including improved ecological safety, accessibility, reproducibility, practicality, and anti-cross-interference capacity. These results highlight the potential of the proposed “two birds with one stone” strategy, providing an integrated methodology for synchronous quantitative detection and derivative identification toward environmental contaminants.
中文翻译：
一石二鸟：比例传感平台克服交叉干扰，实现多场景检测并准确判别四环素类似物
四环素抗生素（TC）造成的环境污染是全球公共卫生的一个主要问题。因此，四环素及其类似物的痕量检测和可靠区分对于确定各种四环素家族成员的分布特征至关重要。这里，通过集成异硫氰酸荧光素（FITC）掺杂的 SiO2 和 Eu3+ 的荧光发射构建了双响应传感器。通过探针固定进一步制造了便携式纸上实验室设备，可以使用智能手机方便地视觉检测四环素。此外，针对多种四环素类似物共存的情况，通过主成分分析对光谱进行降维，实现了应用最广泛的四种四环素类似物（四环素（TC）、金霉素（CTC）、土霉素（OTC）、和多西环素（DOX））。双响应纳米平台实现了从绿色到红色的宽色域颜色变化，光谱仪传感器和纸基传感器的检测限 (LOD) 分别为 2.9 nM 和 89.8 nM。在多个真实样品中检查了分析性能，包括食品、环境和生物环境，证实了强大的环境适应性和抵抗力。与之前的TC传感器相比，该方法有几个显着的改进，包括提高了生态安全性、可访问性、再现性、实用性和抗交叉干扰能力。这些结果凸显了所提出的“一石二鸟”策略的潜力，为环境污染物的同步定量检测和衍生物识别提供了综合方法。
更新日期：2023-07-07
中文翻译：
一石二鸟：比例传感平台克服交叉干扰，实现多场景检测并准确判别四环素类似物
四环素抗生素（TC）造成的环境污染是全球公共卫生的一个主要问题。因此，四环素及其类似物的痕量检测和可靠区分对于确定各种四环素家族成员的分布特征至关重要。这里，通过集成异硫氰酸荧光素（FITC）掺杂的 SiO2 和 Eu3+ 的荧光发射构建了双响应传感器。通过探针固定进一步制造了便携式纸上实验室设备，可以使用智能手机方便地视觉检测四环素。此外，针对多种四环素类似物共存的情况，通过主成分分析对光谱进行降维，实现了应用最广泛的四种四环素类似物（四环素（TC）、金霉素（CTC）、土霉素（OTC）、和多西环素（DOX））。双响应纳米平台实现了从绿色到红色的宽色域颜色变化，光谱仪传感器和纸基传感器的检测限 (LOD) 分别为 2.9 nM 和 89.8 nM。在多个真实样品中检查了分析性能，包括食品、环境和生物环境，证实了强大的环境适应性和抵抗力。与之前的TC传感器相比，该方法有几个显着的改进，包括提高了生态安全性、可访问性、再现性、实用性和抗交叉干扰能力。这些结果凸显了所提出的“一石二鸟”策略的潜力，为环境污染物的同步定量检测和衍生物识别提供了综合方法。
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