使用 ESI-MS 的喷雾电流和泰勒锥顶角对有和没有外部液体泵的电喷雾进行反馈控制,Analytical Chemistry

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使用 ESI-MS 的喷雾电流和泰勒锥顶角对有和没有外部液体泵的电喷雾进行反馈控制
Analytical Chemistry ( IF 6.7 ) Pub Date : 2023-07-07 , DOI: 10.1021/acs.analchem.3c01768
Zhongbao Han ₁ , Shoki Hishida ₁ , Nozomu Omata ₁ , Takeshi Matsuda ₁ , Ryoki Komori ₁ , Lee Chuin Chen ₁

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在稳定锥射流模式下运行的电喷雾高度稳定，但由于流速、表面张力和静电变量的变化，运行状态可能会转变为脉动或多射流模式。这里，使用喷雾电流和泰勒锥的顶角开发了一个简单的反馈控制系统，以确定用于校正发射器电压的误差信号。该系统用于锁定锥射流模式操作以防止外部扰动。对于调节流量下的泵驱动电喷雾，泰勒锥的顶角随着电压的增加而减小。相反，对于具有低流阻的电压驱动电喷雾，发现角度随着发射器电压的增加而增加。使用个人计算机制定并实现了基于迭代学习控制的简单算法，以响应误差信号自动校正发射极电压。对于电压驱动电喷雾电离 (ESI)，喷雾电流的反馈控制也可用于将流量调节至任意值或模式。具有反馈控制的电喷雾电离质谱 (ESI-MS) 被证明可以产生具有长期稳定性的离子信号采集，并且不受模拟的外部干扰的影响。

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Feedback Control of Electrospray with and without an External Liquid Pump Using the Spray Current and the Apex Angle of a Taylor Cone for ESI-MS

An electrospray operated in the steady cone-jet mode is highly stable but the operating state can shift to pulsation or multijet modes owing to changes in flow rate, surface tension, and electrostatic variables. Here, a simple feedback control system was developed using the spray current and the apex angle of a Taylor cone to determine the error signal for correcting the emitter voltage. The system was applied to lock the cone-jet mode operation against external perturbations. For a pump-driven electrospray at a regulated flow rate, the apex angle of the Taylor cone decreased with increasing voltage. In contrast, for a voltage-driven electrospray with low flow resistance, the angle was found to increase with the emitter voltage. A simple algorithm based on iterative learning control was formulated and implemented using a personal computer to automatically correct the emitter voltage in response to the error signal. For voltage-driven electrospray ionization (ESI), the feedback control of the spray current can also be used to regulate the flow rate to an arbitrary value or pattern. Electrospray ionization-mass spectrometry (ESI-MS) with feedback control was demonstrated to produce ion signal acquisition with long-term stability that was insusceptible to the emulated external disturbances.

更新日期：2023-07-07

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