持续输送细胞外囊泡的多孔微针贴片可减轻严重的脊髓损伤,Nature Communications

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持续输送细胞外囊泡的多孔微针贴片可减轻严重的脊髓损伤
Nature Communications ( IF 14.7 ) Pub Date : 2023-07-07 , DOI: 10.1038/s41467-023-39745-2
Ao Fang _{1,

2,

3,

4} , Yifan Wang _{1,

4} , Naiyu Guan _{1,

2,

3,

4} , Yanming Zuo _{1,

2,

3} , Lingmin Lin _{2,

3} , Binjie Guo _{2,

3} , Aisheng Mo _{2,

3} , Yile Wu _{2,

3} , Xurong Lin _{2,

3} , Wanxiong Cai _{2,

3} , Xiangfeng Chen _{2,

3,

4} , Jingjia Ye _{2,

3,

4} , Zeinab Abdelrahman _{1,

2,

3,

4} , Xiaodan Li _{1,

2,

3,

4} , Hanyu Zheng _{2,

3} , Zhonghan Wu _{2,

3} , Shuang Jin _{2,

3} , Kan Xu ₄ , Yan Huang ₅ , Xiaosong Gu ₆ , Bin Yu ₆ , Xuhua Wang _{1,

2,

3,

4,

7}

Affiliation

Department of Rehabilitation Medicine of First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, 310003, Hangzhou, Zhejiang Province, P. R. China.
Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, 1369 West Wenyi Road, 311121, Hangzhou, China.
NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, 310058, Hangzhou, China.
Department of Orthopedics of 2nd Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang Province, PR China.
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, 226001, Nantong, China.
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Co-innovation Center of Neuroregeneration, Nantong University, 226001, Nantong, Jiangsu, P. R. China.

间充质干细胞衍生的分泌体（尤其是细胞外囊泡）的移植是抑制脊髓损伤引发的神经炎症的一种有前景的疗法。然而，以最小的损伤将细胞外囊泡有效递送至受伤的脊髓仍然是一个挑战。在这里，我们提出了一种用于输送细胞外囊泡以治疗脊髓损伤的装置。我们证明，结合间充质干细胞和多孔微针的装置能够输送细胞外囊泡。我们证明，局部应用于硬脊膜下方的脊髓病变不会损伤病变。我们评估了我们的装置在脊髓挫伤模型中的功效，发现它减少了空腔和疤痕组织的形成，促进血管生成，并提高了附近组织和轴突的存活率。重要的是，持续输送细胞外囊泡至少 7 天可带来显着的功能恢复。因此，我们的装置为脊髓损伤治疗提供了有效且持续的细胞外囊泡递送平台。

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更新日期：2023-07-07

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