Highly selective C3-sulfenylation and C3-selenylation of 3-iodo-5-aryl pyrazolo[1,5-a]pyrimidin-7-amine in water was established to provide a green and effective method for the construction of diverse C3-aryl sulfide and C3-aryl selenide derivatives. This regioselective C3-sulfenylation and C3-selenylation protocol proceeds efficiently in the presence of phase transfer catalyst PEG-400 with moderate to good yields. The strategy offers the advantages of green reaction conditions, a wide range of substrates, and gram-scale synthesis.

中文翻译：

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3-碘-5-芳基吡唑并[1,5-a]嘧啶-7-胺在水中的高选择性C3-磺酰化和C3-硒化

建立了3-碘-5-芳基吡唑并[1,5- a ]嘧啶-7-胺在水中的高选择性C3-磺基化和C3-硒基化反应，为构建多样化的C3-芳基硫醚提供绿色有效的方法和C3-芳基硒化物衍生物。这种区域选择性 C3-磺酰化和 C3-硒化方案在相转移催化剂 PEG-400 存在下有效进行，产率中等至良好。该策略具有反应条件绿色、底物范围广和克级合成等优点。