ABSTRACT

The interaction of nanostructured surfaces with cells is complex and has a profound impact on the behaviour of cells by influencing their adhesion, migration, proliferation, and differentiation. Our studies highlighted the contrasting effects of nanostructured and microstructured surfaces on biological functions. Such contrasting effects include the relative influence of physical and chemical attributes of the nanoscale surface compared to the microscale counterpart. These attributes lead to an altered cellular activity at the bio-nano interface through modulating cell adhesion, proliferation of cells and synthesis of functional proteins. Physical and chemical changes induced by the nanostructure are likely to promote cell adhesion, without introducing chemical functionalities on the surface. This represents a significant advance beyond guiding the tailoring of cellular functionality at the bio-nano surface. This would yield an improved understanding of a rational design of biotic/abiotic interfaces that can promote optimal biological responses, leading to the development of new biomedical technologies.

摘要

纳米结构表面与细胞的相互作用是复杂的，通过影响细胞的粘附、迁移、增殖和分化，对细胞的行为产生深远的影响。我们的研究强调了纳米结构和微米结构表面对生物功能的对比影响。这种对比效应包括纳米级表面与微米级表面相比的物理和化学属性的相对影响。这些属性通过调节细胞粘附、细胞增殖和功能蛋白的合成，导致生物纳米界面上的细胞活性发生改变。纳米结构引起的物理和化学变化可能会促进细胞粘附，而无需在表面引入化学功能。这代表着超越指导生物纳米表面细胞功能定制的重大进步。这将加深对生物/非生物界面合理设计的理解，从而促进最佳生物反应，从而促进新生物医学技术的发展。