Near-Infrared Light-Enhanced Generation of Hydroxyl Radical for Cancer Immunotherapy,Advanced Healthcare Materials

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Near-Infrared Light-Enhanced Generation of Hydroxyl Radical for Cancer Immunotherapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-07-06 , DOI: 10.1002/adhm.202301502
Qianqian Zhang _{1,

2} , Yang Li _{1,

2} , Chunhuan Jiang ₁ , Wenbo Sun ₁ , Jingwei Tao ₁ , Lehui Lu _{1,

2}

Affiliation

Hydroxyl radical (^•OH) as a highly oxidizing reactive oxygen species can induce immunogenic cell death (ICD) in cancer treatment. However, high-efficiency cancer immunotherapy is still a huge challenge due to the low ^•OH generation efficiency in the tumor microenvironment, resulting in insufficient immunogenicity and the poor immune response. Here, a near-infrared (NIR) light-enhanced ^•OH generation strategy is developed for cancer immunotherapy by using a copper-based metal-organic framework (Cu-DBC) nanoplatform. With this strategy, the generation efficiency of ^•OH under NIR irradiation is increased 7.34 times than that without NIR irradiation, which induces robust ICD and immune response, thus leading to primary tumor elimination and the inhibition of distant tumor growth and tumor lung metastasis. Experimental results show that Cu-DBC can induce ^•OH boosting through photothermal (PT)-enhanced Cu-catalytic Fenton-like reaction and photocatalytic electron transfer under NIR light irradiation to amplify tumor ICD for immunotherapy.

中文翻译：

近红外光增强羟基自由基的产生用于癌症免疫治疗

羟基自由基（^· OH）作为一种高氧化性活性氧，可以在癌症治疗中诱导免疫原性细胞死亡（ICD）。^{然而，由于肿瘤微环境中·} OH生成效率低，导致免疫原性不足、免疫反应差，高效的癌症免疫治疗仍然是一个巨大的挑战。在这里，通过使用铜基金属有机框架（Cu-DBC）纳米平台，开发了一种用于癌症免疫治疗的近红外（NIR）光增强^{• OH生成策略。}^{通过该策略，近红外辐射下·} OH的生成效率比无近红外辐射时提高了7.34倍，从而诱导了强大的ICD和免疫反应，从而导致原发肿瘤消除并抑制远处肿瘤生长和肿瘤肺转移。实验结果表明，Cu-DBC 可以通过光热（PT）增强的铜催化类芬顿反应和近红外光照射下的光催化电子转移来诱导^{• OH 增强，从而放大肿瘤 ICD，用于免疫治疗。}

更新日期：2023-07-06

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