Cyanation and Hydrolysis Cascade of Aryl Bromides with Cuprous Cyanide to Access Primary Amides,Synlett

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Cyanation and Hydrolysis Cascade of Aryl Bromides with Cuprous Cyanide to Access Primary Amides
Synlett ( IF 1.7 ) Pub Date : 2023-07-04 , DOI: 10.1055/s-0042-1752717
Chunnian Xia ₁ , Bo Hong ₂ , Xiaolin Chen ₁ , Jiawei Dai ₁ , Feng Gao ₁ , Ning Wang ₁ , Junfeng Wang ₃ , Xiao Xiao ₁ , Fengli Dai ₃ , Yifang Li ₄

Affiliation

A convenient and efficient approach for the cyanation and hydrolysis of aryl bromides to afford primary amides was developed, in which cuprous cyanide is used as a cyanide source and a catalyst. It has the advantages of excellent functional-group compatibility, medium to high yields, a one-pot procedure, and a non-noble-metal catalyst. The reaction could be performed on a gram scale to give N-allyl-N-methyl-5-nitroisophthalamide in a 73% yield.

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