Abstract

Ferroptosis is a novel form of cell death, manifested by iron-dependent, non-apoptotic manner resulting from the intracellular accumulation of large clusters of reactive oxygen species (ROS) and lipid peroxides due to abnormal iron metabolism. Since the liver is the main organ of human body for storing iron, it is essential to perform in-depth investigation on the role and mechanistic basis of ferroptosis in the context of divergent liver diseases. We previously summarized the emerging role of ferroptosis among various liver diseases, however, the past few years have been a surge in research establishing ferroptosis as the molecular basis or treatment option. This review article concentrated on the accumulating research progress of ferroptosis in a range of liver diseases such as acute liver injury/failure (ALI/ALF), immune-mediated hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease and liver fibrosis. Ferroptosis may be a promising target for the prevention and treatment of various liver diseases, providing a strategy for exploring new therapeutic avenues for these entities.

摘要

铁死亡是一种新型的细胞死亡形式，表现为铁依赖性、非凋亡方式，是由于铁代谢异常导致细胞内大量活性氧（ROS）和脂质过氧化物的积累而导致的。由于肝脏是人体储存铁的主要器官，因此有必要在不同的肝脏疾病背景下深入研究铁死亡的作用和机制基础。我们之前总结了铁死亡在各种肝脏疾病中的新兴作用，然而，过去几年将铁死亡作为分子基础或治疗选择的研究激增。本文重点介绍了铁死亡在急性肝损伤/肝衰竭（ALI/ALF）、免疫介导性肝炎、酒精性肝病（ALD）、非酒精性脂肪性肝病和肝病等一系列肝病中的研究进展。纤维化。铁死亡可能是预防和治疗各种肝脏疾病的一个有前景的靶点，为探索这些实体的新治疗途径提供了策略。