肿瘤放射治疗中的放射性皮肤损伤护理：机制、药物治疗和新型生物材料应用策略,Advanced Therapeutics

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肿瘤放射治疗中的放射性皮肤损伤护理：机制、药物治疗和新型生物材料应用策略
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2023-07-04 , DOI: 10.1002/adtp.202300024
Yiren Wang ₁ , Lei Yang ₂ , Bo Liu ₁ , Shuang Liao ₁ , Xiao Fu _{3,

4} , Yun Zhou ₅ , Ping Zhou ₆

Affiliation

放射性皮肤损伤（RSI）是恶性肿瘤放射治疗的常见不良反应。它通常会导致患者生活质量下降等问题，并干扰放射治疗 (RT) 的正常过程。随着肿瘤发病率的上升和接受放疗的患者数量的迅速增加，RSI 的护理在癌症患者的治疗中至关重要。目前，药物和生物材料广泛用于RSI的治疗。然而，目前 RSI 的治疗方案尚未达成国际共识。许多药物和生物材料无法应用于适当类型的放射性皮炎，导致RSI的治疗效果不佳。选择合适的药物和生物材料来治疗不同类型的 RSI 对于改善患者的生活质量至关重要。本文首先综述了急性和慢性RSI的主要机制。随后，总结了药物和新型生物材料在 RSI 预防、急性和慢性阶段治疗中的应用。最后，讨论了新型生物材料在 RSI 护理中应用的建议和方案，以及组合生物材料和综合护理解决方案发展的当前挑战和未来前景。

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Radiation Skin Injury Care in Radiotherapy for Oncology: Mechanisms, Drug Therapy and Novel Biomaterial Application Strategies

Radiation skin injury (RSI) is a frequent adverse effect of radiation therapy for malignant tumors. It often leads to problems such as decreased quality of life in patients and interferes with the normal course of radiation therapy (RT). With the rising incidence of tumors and the burgeoning number of patients undergoing RT, the care of RSI is of crucial importance in cancer patient treatment. Currently, drugs and biomaterials are widely used in the care of RSI. However, there is no international consensus on the current protocol for the therapeutic care of RSI. Many drugs and biomaterials cannot be applied to the appropriate type of radiation dermatitis, resulting in unfavorable results in the therapeutic care of RSI. The choice of appropriate drugs and biomaterials for the therapeutic care of the different types of RSI is essential to improving the quality of life of patients. This article first reviews the main mechanisms of acute and chronic RSI. Subsequently, the application of drugs and novel biomaterials in the preventive, acute, and chronic phases of the care of RSI is summarized. Finally, the suggestions and protocols for the application of novel biomaterials in the care of RSI are discussed, as are the current challenges and future prospects for the development of combined biomaterials and integrated care solutions.

更新日期：2023-07-04

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