We introduce 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin as a widely applicable scaffold for the stapling and multicyclisation of cysteine-containing peptides. A robust and peptide-compatible Nucleophilic Aromatic Substitution between aromatic fluorides and cysteine thiols was performed with a library of peptides, leading to different cyclic species – one of which was biologically tested – and offering relevant synthetic insights.

中文翻译：

---

5,10,15,20-四(五氟苯基)卟啉作为肽装订和多环化的功能平台

我们引入 5,10,15,20-四（五氟苯基）卟啉作为广泛适用的支架，用于含半胱氨酸肽的装订和多环化。使用肽库在芳香族氟化物和半胱氨酸硫醇之间进行稳健且肽相容的芳香族取代，产生不同的环状物质（其中一种经过了生物学测试）并提供了相关的合成见解。