Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug. The traditional batch synthesis process suffers from long reaction times, tedious operations, and unstable yields. Herein, a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed. The acylation reaction was completed in a continuous coil reactor at 160 °C in 20 min. And the high toxic solvent pyridine was replaced by acetonitrile. Furthermore, the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip. Combining with the membrane phase separators, the residence time of the purification step was 30 s. The isolated yield of this sequential continuous process was 92% with 99% purity.

二丁酰环磷酸腺苷钙是一种广泛使用的心血管药物。传统的间歇合成工艺存在反应时间长、操作繁琐、收率不稳定等问题。在此，开发了二丁酰腺苷环磷酸钙的顺序连续流合成与多级在线纯化工艺相结合。酰化反应在连续盘管反应器中于160℃下于20分钟内完成。并用乙腈代替高毒溶剂吡啶。此外，将多级在线净化过程集成到自制的3D圆形旋风式微混合器芯片中。与膜相分离器结合，纯化步骤的停留时间为30秒。该顺序连续工艺的分离收率为 92%，纯度为 99%。