This study describes the nickel-catalyzed reductive decarboxylative/deaminative glycosylation of activated aliphatic acids/amines. Various alkyl C-glycosides were efficiently constructed under simple and mild reaction conditions. The reactions were high-yielding and exhibited a broad substrate scope, thereby enabling the transformation of some structurally complex natural products and late-stage modifications of drugs.

中文翻译：

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镍催化活化脂肪酸和伯胺的还原脱羧/脱氨基糖基化

本研究描述了镍催化的活化脂肪酸/胺的还原脱羧/脱氨基糖基化。在简单温和的反应条件下有效构建了各种烷基C-糖苷。该反应产率高，底物范围广泛，从而能够实现一些结构复杂的天然产物的转化和药物的后期修饰。