1,3,4-Oxadiazole is a five-membered heterocyclic compound with one oxygen, two nitrogen, and two carbon atoms arranged in a ring. Several research reports, patents, and marketed drugs have already established 1,3,4-oxadiazole and its analog as potential molecules having a diverse range of pharmacological activities. In this review, we focused on recently acknowledged straightforward synthesis approaches for 1,3,4-oxadiazole and its analogs. Additionally, interactions of the 1,3,4-oxadiazole derivative with different biological targets (enzymes and receptors) have been described. The present findings discussed in this review analysis will aid researchers in conducting future research on 1,3,4-oxadiazole.

中文翻译：

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1,3,4-恶二唑及其类似物：最近采用的合成方法及其与靶标的相互作用

1,3,4-恶二唑是一种五元杂环化合物，具有一个氧、两个氮和两个碳原子排列成环。一些研究报告、专利和上市药物已经确定 1,3,4-恶二唑及其类似物是具有多种药理活性的潜在分子。在这篇综述中，我们重点关注最近公认的 1,3,4-恶二唑及其类似物的直接合成方法。此外，还描述了 1,3,4-恶二唑衍生物与不同生物靶标（酶和受体）的相互作用。本综述分析中讨论的当前发现将有助于研究人员开展 1,3,4-恶二唑的未来研究。