Iron-Catalyzed Oxidative C−C Bond Cleavage of Unstrained Tertiary Alkyl Aromatics to Arylketones,Advanced Synthesis & Catalysis

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Iron-Catalyzed Oxidative C−C Bond Cleavage of Unstrained Tertiary Alkyl Aromatics to Arylketones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2023-07-02 , DOI: 10.1002/adsc.202300410
Ning Xu ₁ , Lulu Zhou ₂ , Linlin Zhao ₃ , Mengying Guo ₃ , Linlin Yang ₃ , Wei Han ₂

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We present here an iron-catalyzed oxidative C_sp3−C_sp3 bond cleavage of unstrained tertiary alkyl aromatics to provide a range of synthetically useful arylketones even with H₂O₂ as the oxidant. This method is operationally simple, scalable, and eco-friendly, as well as suitable for the late-stage oxidation of complex molecules bearing hydroxy groups, making it a valuable tool in organic synthesis.

中文翻译：

铁催化氧化 C−C 键将无张力叔烷基芳烃裂解为芳基酮

我们在此提出了一种铁催化的无张力叔烷基芳族化合物的氧化C _{sp 3} -C _{sp 3}键断裂，以提供一系列合成上有用的芳基酮，甚至使用H ₂ O ₂作为氧化剂。该方法操作简单、可扩展且环保，并且适用于带有羟基的复杂分子的后期氧化，使其成为有机合成中的有价值的工具。

更新日期：2023-07-02

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