Since bisphenol A (BPA) and dimethyl bisphenol A (DM-BPA) are human endocrine disruptors (EDCs) with tiny potential differences (44 mV) and widespread applications, there is a lack of published reports on their simultaneous detection. Therefore, this study reports a novel electrochemical detection system capable of simultaneous direct detection of BPA and DM-BPA using screen-printed carbon electrodes (SPCE) as a sensing platform. To improve the electrochemical performance of the SPCE, the SPCE was modified by using a combination of Pt nanoparticles modified with single-walled carbon nanotubes (Pt@SWCNTs), MXene (Ti₃C₂), and graphene oxide (GO). In addition, the GO in Pt@SWCNTs-MXene-GO was reduced to reduced graphene oxide (rGO) by the action of electric field (−1.2 V), which significantly improved the electrochemical properties of the composites and effectively solved the problem of dispersion of the modified materials on the electrode surface. Under optimal experimental conditions, Pt@SWCNTs-Ti₃C₂-rGO/SPCE exhibited a suitable detection range (0.006–7.4 μmol L⁻¹) and low detection limits (2.8 and 3 nmol L⁻¹, S/N = 3) for the simultaneous detection of BPA (0.392 V vs. Ag/AgCl) and DM-BPA (0.436 V vs. Ag/AgCl)). Thus, this study provides new insights into detecting compounds with similar structures and slight potential differences. Finally, the developed sensor's reproducibility, stability, interference resistance and accuracy were demonstrated with satisfactory results.

由于双酚A（BPA）和二甲基双酚A（DM-BPA）是电位差微小（44 mV）且应用广泛的人类内分泌干扰物（EDC），因此目前缺乏对其同时检测的公开报道。因此，本研究报告了一种新型电化学检测系统，能够使用丝网印刷碳电极（SPCE）作为传感平台同时直接检测 BPA 和 DM-BPA。为了提高SPCE的电化学性能，通过使用单壁碳纳米管（Pt@SWCNTs）、MXene（Ti ₃ C ₂）和氧化石墨烯（GO）改性的Pt纳米颗粒的组合对SPCE进行改性。此外，Pt@SWCNTs-MXene-GO中的GO在电场（-1.2 V）的作用下被还原为还原氧化石墨烯（rGO），显着改善了复合材料的电化学性能，有效解决了分散问题电极表面的改性材料。在最佳实验条件下，Pt@SWCNTs-Ti ₃ C ₂ -rGO/SPCE表现出合适的检测范围（0.006–7.4 μmol L ^-1）和较低的检测限（2.8和3 nmol L ^-1，S/N = 3）用于同时检测 BPA（0.392 V vs. Ag/AgCl）和 DM-BPA（0.436 V vs. Ag/AgCl））。因此，这项研究为检测具有相似结构和轻微电位差异的化合物提供了新的见解。最后，所开发的传感器的重复性、稳定性、抗干扰性和准确性得到了令人满意的结果。