Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation,Angewandte Chemie International Edition

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Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-06-30 , DOI: 10.1002/anie.202307782
Sona Krajcovicova _{1,

2} , David R Spring ₁

Affiliation

Two-component peptide stapling is an appealing method for preparing enzymatically stable peptides with incorporated biologically relevant tags. An unprecedented approach, utilising the tryptophan-mediated multicomponent Petasis reaction (TMPR), facilitates the generation of stapled peptides and enables their late-stage functionalisation. A variety of examples are presented to highlight the advantages of the method.

中文翻译：

用于肽装订和后期功能化的多组分 Petasis 反应中的色氨酸

双组分肽装订是一种有吸引力的方法，用于制备带有生物相关标签的酶稳定肽。一种前所未有的方法，利用色氨酸介导的多组分 Petasis 反应 (TMPR)，促进了钉合肽的生成并使其能够进行后期功能化。提供了各种示例来突出该方法的优点。

更新日期：2023-06-30

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