This paper reports the development of a hydrogel film with antibacterial activity and controlled release characteristics. Carboxymethyl chitosan (CMCS) is grafted onto durancin GL and inulin via a mediated reaction between N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. Rheology tests, Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy, and lap shear tests confirmed the formation of a stable chemical cross-linking and excellent adhesion hydrogel with 4 % CMCS and 8 % inulin. The CMCS/inulin hydrogel film loaded with durancin GL appears transparent and uniform. FTIR spectroscopy results reveal the interaction mode among CMCS, inulin, durancin GL, and the hydrogel film structure. Cross-linking improved thermal stability and water-vapour barrier performance. The hydrophobicity of CMCS/inulin @Durancin GL increased under a durancin GL concentration of 0.036 g/30 mL, and the release of active substances is prolonged. In-vitro antibacterial capacity and salmon preservation experiments show that the addition of durancin GL enhanced the antibacterial activity of the hydrogel film. Therefore, CMCS/inulin@Durancin GL hydrogel films can be used as fresh-keeping packaging materials in practical applications.

本文报道了具有抗菌活性和控释特性的水凝胶薄膜的开发。通过 N-羟基琥珀酰亚胺和 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺盐酸盐之间的介导反应，将羧甲基壳聚糖 (CMCS) 接枝到 durancin GL 和菊粉上。流变学测试、傅里叶变换红外 (FTIR) 光谱、X 射线光电子能谱和搭接剪切测试证实，含有 4% CMCS 和 8% 菊粉的水凝胶形成了稳定的化学交联和优异的附着力。负载有 durancin GL 的 CMCS/菊粉水凝胶膜显得透明且均匀。FTIR 光谱结果揭示了 CMCS、菊粉、durancin GL 和水凝胶膜结构之间的相互作用模式。交联提高了热稳定性和水蒸气阻隔性能。durancin GL浓度为0.036 g/30 mL时，CMCS/菊粉@Durancin GL的疏水性增加，活性物质的释放时间延长。体外抗菌能力和鲑鱼保存实验表明，durancin GL的添加增强了水凝胶膜的抗菌活性。因此，CMCS/inulin@Durancin GL水凝胶薄膜在实际应用中可以作为保鲜包装材料。