A series of novel 1,2,3,4-tetrahydro[1,2,4]triazino[4,5-a]benzimidazoles carrying variety of aryl and heteroaryl groups at position 1 were synthesized. The newly synthesized compounds were tested in vitro on human breast adenocarcinoma cell line (MCF7). Some of the test compounds showed potent antitumor activity, especially compound 3c [1-(2-chlorophenyl) derivative] which displayed the highest activity among the test compounds.

中文翻译：

---

新型[1,2,4]三嗪[4,5- a ]苯并咪唑衍生物的合成，抗肿瘤活性和SAR研究

合成了一系列新颖的1,2,3,4-四氢[1,2,4]三嗪基[4,5- a ]苯并咪唑在位置1带有各种芳基和杂芳基。新合成的化合物在人乳腺癌细胞系（MCF7）上进行了体外测试。一些测试化合物显示出有效的抗肿瘤活性，尤其是化合物3c [1-（2-氯苯基）衍生物]在测试化合物中显示出最高的活性。