Langmuir-Blodgett 介导的抗菌微针形成用于长期透皮给药,Advanced Materials

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Langmuir-Blodgett 介导的抗菌微针形成用于长期透皮给药
Advanced Materials ( IF 27.4 ) Pub Date : 2023-06-29 , DOI: 10.1002/adma.202303388
Ziyi Lu ₁ , Shan Du ₁ , Jiaxun Li ₂ , Min Zhang ₃ , Huali Nie ₁ , Xiaojun Zhou ₁ , Fulun Li ₄ , Xinwei Wei ₅ , Jinqiang Wang ₅ , Fuyao Liu ₅ , Chuanglong He ₁ , Guang Yang _{1,

6} , Zhen Gu _{5,

7,

8,

9,

10,

11}

Affiliation

Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
College of Basic Medicine, Naval Medical University, Shanghai, 200433, China.
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, China.
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Jinhua Institute of Zhejiang University, Jinhua, 321299, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China.
National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, 310058, China.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

微针 (MN) 已成为微创透皮给药装置的多功能平台。然而，人们担心长期透皮给药会引起微核引起的皮肤感染。使用 Langmuir-Blodgett (LB) 技术，开发了一种将各种形状、尺寸和成分的抗菌纳米粒子沉积到 MN 上的简单方法。该策略比传统的浸涂技术具有优点，包括受控的涂层、均匀且高的覆盖率以及简单的制造工艺。这为 MN 提供了快速、持久的抗菌作用。这项研究表明，抗菌微纳米粒子在体外和体内均能实现优异的细菌消除效果，且不会牺牲有效负载能力、药物释放或机械强度。人们认为，这种功能性纳米颗粒涂层技术为扩展MNs功能提供了一个平台，特别是在长期透皮给药领域。

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更新日期：2023-06-29

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