Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides,Chemistry & Biodiversity

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Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-06-28 , DOI: 10.1002/cbdv.202300821
Song-Wei Li ₁ , Jiao Liu ₂ , Yan Fu ₂ , Li-Gong Yao ₂ , Hai-Yan Zhang ₂ , Hong Wang ₁ , Yue-Wei Guo _{1,

2,

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Affiliation

Three new steroids, along with two known related analogs, were isolated from the Xisha Island soft coral Lobophytum sarcophytoides. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic data analyses, time dependent density functional theory electronic circular dichroism calculation, and comparison with the spectral data previously reported in the literature. In in vitro bioassay, four compounds showed interesting suppressive effects on lipopolysaccharide (LPS) induced inflammation in BV-2 microglial cells at 10 μM level.

中文翻译：

来自南海软珊瑚 Lobophytum sarcophytoides 的抗炎类固醇

从西沙岛软珊瑚Lobophytum sarcophytoides中分离出三种新的类固醇以及两种已知的相关类似物。通过广泛的光谱数据分析、时间相关密度泛函理论电子圆二色性计算以及与文献中先前报道的光谱数据的比较，阐明了新化合物的结构和绝对构型。在体外生物测定中，四种化合物在 10 μM 水平下对脂多糖 (LPS) 诱导的 BV-2 小胶质细胞炎症表现出有趣的抑制作用。

更新日期：2023-06-28

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