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Eye-Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins
Advanced Materials ( IF 27.4 ) Pub Date : 2023-06-28 , DOI: 10.1002/adma.202302996
Byeongho Park 1 , Seokyoung Bang 2 , Kyeong Seob Hwang 1, 3 , Yeon Kyung Cha 1 , Jisung Kwak 1 , Na Ly Tran 1, 4 , Hyo-Suk Kim 1 , Subeen Park 1 , Seung Ja Oh 1, 4 , Maesoon Im 1 , Sooyoung Chung 1 , Jongbaeg Kim 3 , Tai Hyun Park 5 , Hyun Seok Song 1 , Hong Nam Kim 1, 3, 4, 6 , Jae Hun Kim 1
Advanced Materials ( IF 27.4 ) Pub Date : 2023-06-28 , DOI: 10.1002/adma.202302996
Byeongho Park 1 , Seokyoung Bang 2 , Kyeong Seob Hwang 1, 3 , Yeon Kyung Cha 1 , Jisung Kwak 1 , Na Ly Tran 1, 4 , Hyo-Suk Kim 1 , Subeen Park 1 , Seung Ja Oh 1, 4 , Maesoon Im 1 , Sooyoung Chung 1 , Jongbaeg Kim 3 , Tai Hyun Park 5 , Hyun Seok Song 1 , Hong Nam Kim 1, 3, 4, 6 , Jae Hun Kim 1
Affiliation
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An in vitro model, composed of the short-wavelength human opsins and rhodopsins, is created. Two types of photosensitive neural spheroids are transfected for selective reaction under bluish-purple and green lights. These are employed to two devices with intact neuron and neural-spheroid to study the interaction. By photostimulation, the photosensitive spheroid initiated photoactivation, and the signal generated from its body is transmitted to adjacent neural networks. Specifically, the signal traveled through the axon bundle in narrow gap from photosensitive spheroid to intact spheroid as an eye-to-brain model including optic nerve. The whole process with photosensitive spheroid is monitored by calcium ion detecting fluorescence images. The results of this study can be applied to examine vision restoration and novel photosensitive biological systems with spectral sensitivity.
中文翻译:
由具有人类视蛋白的光敏神经球体组成的仿眼神经网络
创建了由短波长人视蛋白和视紫红质组成的体外模型。转染两种类型的光敏神经球体,在蓝紫色和绿光下进行选择性反应。这些被用于具有完整神经元和神经球体的两个设备来研究相互作用。通过光刺激,光敏球体启动光激活,其身体产生的信号被传输到邻近的神经网络。具体来说,信号通过轴突束以狭窄的间隙从光敏球体传播到完整的球体,作为包括视神经的眼到脑模型。通过钙离子检测荧光图像来监测光敏球体的整个过程。这项研究的结果可用于检查视力恢复和具有光谱敏感性的新型光敏生物系统。
更新日期:2023-06-28
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
由具有人类视蛋白的光敏神经球体组成的仿眼神经网络
创建了由短波长人视蛋白和视紫红质组成的体外模型。转染两种类型的光敏神经球体,在蓝紫色和绿光下进行选择性反应。这些被用于具有完整神经元和神经球体的两个设备来研究相互作用。通过光刺激,光敏球体启动光激活,其身体产生的信号被传输到邻近的神经网络。具体来说,信号通过轴突束以狭窄的间隙从光敏球体传播到完整的球体,作为包括视神经的眼到脑模型。通过钙离子检测荧光图像来监测光敏球体的整个过程。这项研究的结果可用于检查视力恢复和具有光谱敏感性的新型光敏生物系统。