具有快速热响应凝胶化和强大湿粘附力的仿生多功能止血水凝胶用于紧急止血：基于光交联协调亲水-疏水平衡策略的合理设计,Biomacromolecules

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具有快速热响应凝胶化和强大湿粘附力的仿生多功能止血水凝胶用于紧急止血：基于光交联协调亲水-疏水平衡策略的合理设计
Biomacromolecules ( IF 5.5 ) Pub Date : 2023-06-27 , DOI: 10.1021/acs.biomac.3c00357
Hongyang Song ₁ , Lei Xing ₁ , Wentao Liu ₂ , Xue Wang ₁ , Zhaosheng Hou ₃ , Yue Wang ₁ , Zhenhao Zhang ₁ , Yiming Li ₁ , Tianduo Li ₁ , Xiaolong Wang ₄ , Hui Chen ₂ , Shu Xing ₁ , Jing Xu ₁

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紧急情况下失控的出血对军人和平民的生命均构成极大威胁，目前急需但仍缺乏一种能有效控制院前出血的理想止血剂。尽管止血水凝胶在紧急止血方面具有广阔的前景，但目前它们面临着凝胶时间短和粘合网络强的相互排斥、成分功能不足和原位固化操作复杂等挑战。在此，合理设计了一种基于细胞外基质生物聚合物的多功能止血水凝胶，它同时集成了快速热响应凝胶化、强大的湿粘附性和在紧急情况下的易用性。这种水凝胶可以通过简单的注射方便地使用，并在体温下实现即时溶胶-凝胶相变。其综合性能可以通过调整组分比例来方便地调节，并且由于光的协调增强而建立了最佳性能（凝胶时间6-8秒，粘合强度125±3.6kPa，爆破压力282±4.1mmHg） -交联预处理和水凝胶系统中各种相互作用之间的亲水-疏水平衡。此外，它还具有显着的凝血作用在体外并能在体内有效止血和伤口愈合。这项工作为水凝胶基材料的多功能应用（包括紧急止血）提供了一个有前途的平台。

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Biomimetic and Multifunctional Hemostatic Hydrogel with Rapid Thermoresponsive Gelation and Robust Wet Adhesion for Emergency Hemostasis: A Rational Design Based on Photo-Cross-Linking Coordinated Hydrophilic–Hydrophobic Balance Strategies

Uncontrolled bleeding in emergency situations is a great threat to both military and civilian lives, and an ideal hemostat for effectively controlling prehospital hemorrhage is urgently needed but still lacking. Although hemostatic hydrogels are promising for emergency hemostasis, they are currently challenged by either the mutual exclusion between a short gelation time and strong adhesive network or the insufficient functionality of ingredients and complicated operations for in situ curing. Herein, an extracellular matrix biopolymer-based and multifunctional hemostatic hydrogel that simultaneously integrates rapid thermoresponsive gelation, robust wet adhesion, and ease of use in emergencies is rationally engineered. This hydrogel can be conveniently used via simple injection and achieves instant sol–gel phase transition at body temperature. Its comprehensive performance could be facilely regulated by tuning the proportions of components, and the optimal performance (gelation time 6–8 s, adhesion strength 125 ± 3.6 kPa, burst pressure 282 ± 4.1 mmHg) is established due to the coordinated enhancement of the photo-cross-linking pretreatment and the hydrophilic–hydrophobic balance among various interactions in the hydrogel system. Additionally, it exhibits significant coagulation effect in vitro and enables effective hemostasis and wound healing in vivo. This work provides a promising platform for versatile applications of hydrogel-based materials, including emergency hemostasis.

更新日期：2023-06-27

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