In this work, the isothermal vapor–liquid equilibrium (VLE) of trans-1,3,3,3-tetrafluoropropene (HFO-1234ze(E)) and 1,1,1,3,3-pentafluoropropane (HFC245fa) binary system, along with the saturated vapor pressures HFO-1234ze(E) and HFC-245fa, were measured by static-analytic apparatus. The VLE measurements of HFO-1234ze(E) + HFC-245fa binary system are performed at temperatures from (293.28 to 333.09) K, while the measurements for vapor pressures of HFO1234ze(E) and HFC-245fa were conducted in the temperature range of (263.08 to 363.01) K. The vapor pressures were correlated by the Peng-Robinson (PR) equation of state (EoS) associated with the Mathias-Copeman (MC) alpha function, and the VLE data were correlated to the PRMC-vdW model where the MC alpha function and the van der Waals (vdW) mixing rules were combined with the PR EoS. The experimental VLE data were compared with the predictive E-PPR78 model. The modeling results of the PRMC-vdW model had good agreement with the experimental VLE data, while the E-PPR78 model shows negative bias in the prediction of equilibrium pressures. The experimental VLE data were also compared with literature data for consistency checks. The two sets of VLE data were basically consistent, while a discrepancy was found when analyzing the relationship between binary interaction parameter k_ij and temperature.