基于聚集诱导的 I 型和 II 型光敏性和光降解性的分子主链，通过光动力和光热疗法实现协同抗菌和癌症光疗,Materials Horizons

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基于聚集诱导的 I 型和 II 型光敏性和光降解性的分子主链，通过光动力和光热疗法实现协同抗菌和癌症光疗
Materials Horizons ( IF 12.2 ) Pub Date : 2023-06-28 , DOI: 10.1039/d3mh00688c
Jun Liu ₁ , Hongyu Chen ₁ , Yongsheng Yang ₁ , Qihui Wang ₂ , Shilu Zhang ₁ , Bo Zhao ₁ , Zhonghui Li ₁ , Guoqiang Yang ₃ , Guowei Deng ₂

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由于对其光毒性和功效的担忧，光疗纳米材料的临床应用仍然受到限制。在此，我们报道了一种新型的 D-π-A 分子主链，它通过形成 J-聚集体来诱导 I/II 型光敏性和光降解性。光降解速率可以通过改变供体基团来调节其聚集体的光敏性来调节，因为光降解性能是由其II型光敏性产生的¹ O _{2氧化所致。}AID4 NPs因其更好的I型和II型光敏性而具有更快的光降解速度，并且在缺氧条件下还可以通过抑制II型和改善I型进行自我调节。此外，它们表现出良好的光热和光声性能，可通过协同效应提高治疗效果并实现体内光声成像。实验结果还表明，它们可以有效地抗菌和抗肿瘤治疗，并且AID4 NPs的光降解产物在黑暗或光照下具有较低的生物毒性。这项研究可以为提高光疗的安全性和治疗效果提供新的策略。

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Aggregation-induced type I&II photosensitivity and photodegradability-based molecular backbones for synergistic antibacterial and cancer phototherapy via photodynamic and photothermal therapies

The clinical applications of phototherapy nanomaterials are still limited due to concerns regarding their phototoxicity and efficacy. Herein, we report a novel type of D–π–A molecular backbone that induces type I/II photosensitivity and photodegradability by forming J-aggregates. The photodegradation rate can be regulated by changing the donor groups to regulate the photosensitivity of their aggregates because the photodegradability performance results from their oxidation by ¹O₂ generated by their type II photosensitivity. AID4 NPs possess faster photodegradation because of their better type I&II photosensitivity, which can also self-regulate by inhibiting type II and improving type I under hypoxic conditions. Moreover, they exhibited good photothermal and photoacoustic performance for improving their therapeutic effect by a synergistic effect and achieving photoacoustic imaging in vivo. The experimental result also showed that they can be effective for antibacterial and anti-tumor treatment and the photodegradation products of AID4 NPs possess low biological toxicity in the dark or under light. This study could provide a novel strategy for improving the safety and treatment effects of phototherapy.

更新日期：2023-06-28

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