Synthesis and Structural Analysis of N3-Methyluridine and 2’-Alkoxy/Fluoro-N3-Methyluridine Nucleosides by Using NMR Spectroscopy, X-Ray Crystallography, and Computational Methods,ChemistrySelect

当前位置： X-MOL 学术 › ChemistrySelect › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis and Structural Analysis of N3-Methyluridine and 2’-Alkoxy/Fluoro-N3-Methyluridine Nucleosides by Using NMR Spectroscopy, X-Ray Crystallography, and Computational Methods
ChemistrySelect ( IF 1.9 ) Pub Date : 2023-06-22 , DOI: 10.1002/slct.202301858
Avijit Sahoo ₁ , Gourav Das ₁ , Nishant Kumar Choudhary ₁ , S. Harikrishna ₂ , Kiran R. Gore ₁

Affiliation

The X-ray data confirms the C2’-endo conformation for N³-Methyluridine, whereas all the 2’-substituted N³-methyluridine analogs tunes sugar conformation to C3’-endo predominantly. The stereoelectronic effects like anomeric and hyperconjugation effects influence the sugar puckering towards the North conformation due to the presence of electron-withdrawing 2’-alkoxy and fluoro substituents.

中文翻译：

利用核磁共振波谱、X 射线晶体学和计算方法合成 N3-甲基尿苷和 2'-烷氧基/氟-N3-甲基尿苷核苷并进行结构分析

X射线数据证实了N ³ -甲基尿苷的C2'-内构象，而所有2'-取代的N ^{3 -}甲基尿苷类似物主要将糖构象调整为C3'-内构象。由于吸电子 2'-烷氧基和氟取代基的存在，异头效应和超共轭效应等立体电子效应影响糖向North构象折叠。

更新日期：2023-06-22

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南