Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity,Alcoholism: Clinical & Experimental Research

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Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity
Alcoholism: Clinical & Experimental Research Pub Date : 2023-06-25 , DOI: 10.1111/acer.15137
Matthew C Hartmann _{1,

2} , Walter D McCulley ₂ , Sarah E Holbrook _{1,

3} , Megan M Haney ₂ , Caitlin G Smith ₂ , Vivek Kumar _{1,

3} , Alan M Rosenwasser _{1,

2,

4}

Affiliation

Since the origin of the C57BL/6 (B6) mouse strain, several phenotypically and genetically distinct B6 substrains have emerged. For example, C57BL/6J mice (B6J) display greater voluntary ethanol consumption and locomotor response to psychostimulants and differences in nucleus accumbens synaptic physiology relative to C57BL/6N (B6N) mice. A non-synonymous serine to phenylalanine point mutation (S968F) in the cytoplasmic FMR1-interacting protein 2 (Cyfip2) gene underlies both the differential locomotor response to cocaine and the accumbal physiology exhibited by these substrains. We examined whether Cyfip2 allelic variation underlies B6 substrain differences in other reward-related phenotypes, such as ethanol intake and wheel-running activity.

中文翻译：

C57BL/6J 和 C57BL/6NJ 小鼠的 Cyfip2 等位基因变异改变了自由选择的乙醇饮用，但不改变了暴饮暴食或轮式饮酒活动

自 C57BL/6 （B6）小鼠品系起源以来，已经出现了几种表型和遗传学不同的 B6 亚株。例如，相对于 C57BL/6N （B6N）小鼠，C57BL/6J 小鼠（B6J）表现出更大的自主乙醇消耗和对精神兴奋剂的运动反应以及伏隔核突触生理学的差异。细胞质 FMR1 相互作用蛋白 2 （Cyfip2）基因中的非同义丝氨酸到苯丙氨酸点突变（S968F）是可卡因的差异运动反应和这些亚菌株表现出的累积生理学的基础。我们检查了 Cyfip2 等位基因变异是否是其他奖励相关表型（如乙醇摄入和车轮奔跑活动）中 B6 亚菌株差异的基础。

更新日期：2023-06-25

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