Target acquired: Gambogic acid induces apoptosis by directly targeting mitochondria and represents a new class of mitocans. Using fluorescence microscopy and immunblotting, we show that apoptosis is induced by cleavage of caspase‐3 and ‐9 and that induction of the mitochondrial pathway was not related to morphological changes to other subcellular structures.

中文翻译：

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藤黄酸的亚细胞定位和活性


获得的目标：藤黄酸通过直接靶向线粒体来诱导细胞凋亡，代表一类新的线粒体。使用荧光显微镜和免疫印迹，我们表明细胞凋亡是由 caspase-3 和 ‐9 的裂解诱导的，并且线粒体途径的诱导与其他亚细胞结构的形态变化无关。