Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, and cancer progression, suggesting that the cGAS/STING signaling pathway represents an efficient therapeutic target. Based on the accumulated evidence, we present insights into the prevention and treatment of cGAS/STING-related chronic immune and inflammatory diseases. This review presents the current state of clinical and nonclinical development of modulators targeting cGAS/STING, providing useful information on the design of therapeutic strategies.

环单磷酸鸟苷-单磷酸腺苷 (cGAMP) 合酶 (cGAS) 是一种 DNA 传感器，可通过识别普遍存在的危险相关分子来引发强烈的 I 型干扰素反应。 cGAS/干扰素基因刺激剂（cGAS/STING）由内源性 DNA 激活，包括从线粒体和核外染色质释放的 DNA，以及源自病原微生物的外源性 DNA。 cGAS/STING 被定位为自身免疫、炎症反应和癌症进展的关键轴，表明 cGAS/STING 信号通路代表了有效的治疗靶点。基于积累的证据，我们提出了对 cGAS/STING 相关慢性免疫和炎症疾病的预防和治疗的见解。本综述介绍了针对 cGAS/STING 的调节剂的临床和非临床开发现状，为治疗策略的设计提供了有用的信息。