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Anchoring immunosuppression to inflamed tissue
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2023-06-23 , DOI: 10.1038/s41551-023-01055-9 Karina V Mariño 1 , Ada G Blidner 2 , Gabriel A Rabinovich 2, 3
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2023-06-23 , DOI: 10.1038/s41551-023-01055-9 Karina V Mariño 1 , Ada G Blidner 2 , Gabriel A Rabinovich 2, 3
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Fusing the anti-inflammatory enzyme indoleamine 2,3-dioxygenase to the tissue-anchoring protein galectin-3 ameliorates inflammation at the injection site while avoiding systemic immune suppression, as shown in multiple rodent models of inflammation.
中文翻译:
将免疫抑制锚定于发炎组织
将抗炎酶吲哚胺 2,3-双加氧酶与组织锚定蛋白半乳糖凝集素 3 融合可改善注射部位的炎症,同时避免全身免疫抑制,如多种啮齿动物炎症模型所示。
更新日期:2023-06-24
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
将免疫抑制锚定于发炎组织
将抗炎酶吲哚胺 2,3-双加氧酶与组织锚定蛋白半乳糖凝集素 3 融合可改善注射部位的炎症,同时避免全身免疫抑制,如多种啮齿动物炎症模型所示。