基于二维同构 Co/Ni-金属-有机框架的葡萄糖检测非酶电化学传感平台,Inorganic Chemistry

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基于二维同构 Co/Ni-金属-有机框架的葡萄糖检测非酶电化学传感平台
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2023-06-21 , DOI: 10.1021/acs.inorgchem.3c01058
Xin-Ying Wang _{1,

2} , Xue-Xue Yan _{1,

2} , Ya-Pan Wu _{1,

2} , Xue-Qian Wu _{1,

2} , Ya-Meng Yin _{1,

2} , Shuang Li _{1,

2} , Qichun Zhang ₁ , Bin Liu ₁ , Dong-Sheng Li _{1,

2}

Affiliation

二维金属有机骨架（MOF）晶体材料由于其结构可调、高比表面积和丰富的金属活性位点，在电化学传感过程中具有广阔的前景；然而，开发结合电化学活性和环境稳定性的基于 MOF 的非酶葡萄糖 (Glu) 传感器仍然是一个挑战。在此，利用三足氮桥联的1,3,5-三(1-咪唑基)苯(TIB)连接体Co ²⁺和Ni ²⁺，两种二维同构晶体材料，包括Co/Ni-MOF {[Co ( TIB)]·2BF ₄ } ( CTGU-31 ) 和 {[Ni(TIB)]·2NO ₃ } ( CTGU-32 )，具有双节 (3, 6) 连接的kgd首先用导电乙炔黑（AB）合成并制作了拓扑网络。^{当在玻碳电极上进行修饰时，优化的 AB/CTGU-32 (1:1) 电催化剂表现出 2.198 μA μM –1} cm ^–2的更高灵敏度、10 至 4000 μM 更宽的线性范围以及更低的检测限与之前基于 MOF 的 Glu 传感器相比，(LOD) 值（0.09 μM，S / N = 3）。此外，AB/CTGU-32 (1:1) 在电化学过程中表现出至少 2000 秒的理想稳定性。这项工作表明，基于 MOF 的电催化剂是监测 Glu 的有前途的候选者，并展示了它们用于糖尿病初步筛查的潜力。

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Nonenzymatic Electrochemical Sensing Platform Based on 2D Isomorphic Co/Ni-Metal–Organic Frameworks for Glucose Detection

Two-dimensional metal–organic framework (MOF) crystalline materials possess promising potential in the electrochemical sensing process owing to their tunable structures, high specific surface area, and abundant metal active sites; however, developing MOF-based nonenzymatic glucose (Glu) sensors which combine electrochemical activity and environmental stability remains a challenge. Herein, utilizing the tripodic nitrogen-bridged 1,3,5-tris(1-imidazolyl) benzene (TIB) linker, Co²⁺ and Ni²⁺, two 2D isomorphic crystalline materials, including Co/Ni-MOF {[Co (TIB)]·2BF₄} (CTGU-31) and {[Ni(TIB)]·2NO₃} (CTGU-32), with a binodal (3, 6)-connected kgd topological net were firstly synthesized and fabricated with conducting acetylene black (AB). When modified on a glassy carbon electrode, the optimized AB/CTGU-32 (1:1) electrocatalyst demonstrated a higher sensitivity of 2.198 μA μM^–1 cm^–2, a wider linear range from 10 to 4000 μM, and a lower detection limit (LOD) value (0.09 μM, S/N = 3) compared to previously MOF-based Glu sensors. Moreover, AB/CTGU-32 (1:1) exhibited desirable stability for at least 2000 s during the electrochemical process. The work indicates that MOF-based electrocatalysts are a promising candidate for monitoring Glu and demonstrate their potential for preliminary screening for diabetes.

更新日期：2023-06-21

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