Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review,Advanced Science

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Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review
Advanced Science ( IF 14.3 ) Pub Date : 2023-06-21 , DOI: 10.1002/advs.202300672
Qianwen Wu ₁ , Juan Liao ₁ , Huaming Yang _{1,

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Affiliation

Advanced functional two-dimensional (2D) nanomaterials offer unique advantages in drug delivery systems for disease treatment. Kaolinite (Kaol), a nanoclay mineral, is a natural 2D nanomaterial because of its layered silicate structure with nanoscale layer spacing. Recently, Kaol nanoclay is used as a carrier for controlled drug release and improved drug dissolution owing to its advantageous properties such as surface charge, strong biocompatibility, and naturally layered structure, making it an essential development direction for nanoclay-based drug carriers. This review outlines the main physicochemical characteristics of Kaol and the modification methods used for its application in biomedicine. The safety and biocompatibility of Kaol are addressed, and details of the application of Kaol as a drug delivery nanomaterial in antibacterial, anti-inflammatory, and anticancer treatment are discussed. Furthermore, the challenges and prospects of Kaol-based drug delivery nanomaterials in biomedicine are discussed. This review recommends directions for the further development of Kaol nanocarriers by improving their physicochemical properties and expanding the bioapplication range of Kaol.

中文翻译：

高岭石纳米粘土作为生物应用药物载体的最新进展：综述

先进的功能性二维（2D）纳米材料在疾病治疗的药物输送系统中具有独特的优势。高岭石（Kaol）是一种纳米粘土矿物，因其具有纳米级层间距的层状硅酸盐结构而成为一种天然二维纳米材料。近年来，高岭土纳米粘土因其表面电荷、强生物相容性和自然层状结构等有利特性而被用作药物控制释放和改善药物溶出的载体，使其成为纳米粘土药物载体的重要发展方向。本文概述了高岭土的主要理化特性及其在生物医学中应用的改性方法。讨论了高岭土的安全性和生物相容性，并详细讨论了高岭土作为药物递送纳米材料在抗菌、抗炎和抗癌治疗中的应用。此外，还讨论了基于高岭土的药物递送纳米材料在生物医学中的挑战和前景。该综述通过改善高岭土纳米载体的理化性质和扩大高岭土的生物应用范围，为进一步发展高岭土纳米载体提出了方向。

更新日期：2023-06-21

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