Background

Hyperuricemia refers to a metabolic disorder associated with high serum uric acid levels and is regarded as a major risk factor not only for the development of gout but also for various chronic diseases. However, current clinical hypouricemic medications still have some undesired side effects and are contraindicated by multiple comorbidities. Thus, the development of natural therapeutic products as novel, safe, and effective alternatives to pharmacological agents is urgently needed.

Scope and approach

This review mainly focuses on the research progress of phytochemicals in the treatment of hyperuricemia and gout. Additionally, the chemical structure, specific mechanism, and effective dose of natural phytochemicals are comprehensively highlighted.

Key findings and conclusions

Many in vivo and/or in vitro studies have indicated that phytochemicals derived from natural sources, including alkaloids, phenolic acids, and flavonoids, possess the beneficial properties of downregulating uric acid levels and dissolving monosodium urate crystals. Therefore, they have great potential to be novel and safe agents that can prevent and combat hyperuricemia and gout.

中文翻译：

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天然植物化学物质对抗和预防高尿酸血症和痛风的有益特性和机制

背景

高尿酸血症是指与高血清尿酸水平相关的代谢紊乱，被认为不仅是痛风发展的主要危险因素，也是各种慢性疾病的主要危险因素。然而，目前临床上的降尿酸药物仍然存在一些不良副作用，并且因多种合并症而禁忌。因此，迫切需要开发天然治疗产品作为药物制剂的新颖、安全且有效的替代品。

范围和方法

本文主要综述植物化学物质在治疗高尿酸血症和痛风方面的研究进展。此外，还全面阐述了天然植物化学物质的化学结构、具体作用机制和有效剂量。

主要发现和结论

许多体内和/或体外研究表明，源自天然来源的植物化学物质，包括生物碱、酚酸和黄酮类化合物，具有下调尿酸水平和溶解尿酸钠晶体的有益特性。因此，它们具有成为预防和对抗高尿酸血症和痛风的新型安全药物的巨大潜力。