Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors,Chemical Reviews

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Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors
Chemical Reviews ( IF 51.4 ) Pub Date : 2023-06-21 , DOI: 10.1021/acs.chemrev.3c00039
Jorn de Jong ₁ , Jasper E Bos ₁ , Sander J Wezenberg ₁

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Anionic species are omnipresent and involved in many important biological processes. A large number of artificial anion receptors has therefore been developed. Some of these are capable of mediating transmembrane transport. However, where transport proteins can respond to stimuli in their surroundings, creation of synthetic receptors with stimuli-responsive functions poses a major challenge. Herein, we give a full overview of the stimulus-controlled anion receptors that have been developed thus far, including their application in membrane transport. In addition to their potential operation as membrane carriers, the use of anion recognition motifs in forming responsive membrane-spanning channels is discussed. With this review article, we intend to increase interest in transmembrane transport among scientists working on host–guest complexes and dynamic functional systems in order to stimulate further developments.

中文翻译：

合成受体刺激控制的阴离子结合和运输

阴离子种类无处不在并参与许多重要的生物过程。因此开发了大量的人工阴离子受体。其中一些能够介导跨膜运输。然而，当转运蛋白可以对其周围环境的刺激做出反应时，具有刺激响应功能的合成受体的创建提出了重大挑战。在此，我们全面概述了迄今为止已开发的刺激控制阴离子受体，包括它们在膜运输中的应用。除了作为膜载体的潜在作用外，还讨论了阴离子识别基序在形成响应性跨膜通道中的用途。通过这篇综述文章，我们打算提高从事主客体复合物和动态功能系统研究的科学家对跨膜运输的兴趣，以刺激进一步的发展。

更新日期：2023-06-21

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