用于体外成骨的压电 PDMS/AlN 薄膜,ACS Biomaterials Science & Engineering

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用于体外成骨的压电 PDMS/AlN 薄膜
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2023-06-21 , DOI: 10.1021/acsbiomaterials.3c00196
Haotian Tang ₁ , Youtian Mo _{2,

3} , Wei Li ₁ , Han Hu _{2,

3} , Liang Chen _{2,

3} , Rui Zhu ₁ , Dongliang Zhang ₁ , Peidong Ouyang _{2,

3} , Wenliang Wang _{2,

3} , Guoqiang Li _{2,

3} , Jing Tian ₁

Affiliation

骨缺损和骨不连是由于骨再生不足而难以治疗的复杂疾病。电刺激作为一种有前途的诱导和增强骨再生的策略而引起了人们的关注。自供电和生物相容性材料由于能够在无需外部电源的情况下产生电刺激，因此已被广泛探索并用于生物医学设备。我们的目的是制备具有优异生物相容性和骨传导能力的压电聚二甲基硅氧烷（PDMS）/氮化铝（AlN）薄膜，用于小鼠颅骨前成骨细胞MC3T3-E1细胞的生长。通过施加振动刺激身体运动，PDMS/AlN 薄膜表现出 2–6 μA cm ^{–2的电流密度}，产生的连续交流电（AC）有效促进MC3T3-E1细胞的生长、活力和成骨细胞相关基因表达（基因runt相关转录因子2[RUNX2]、骨钙素[OCN]、碱性磷酸酶[ ALP ] ）并表现出矿化度较高。与空白板和非振动PDMS/AlN膜相比，振动PDMS/AlN膜显示出快速且优异的成骨分化。生物相容性柔性压电PDMS/AlN薄膜的设计克服了传统电活性材料加工性能差、脆性大、电刺激不稳定性等问题，展现了电刺激在骨组织工程中应用的巨大潜力。

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Piezoelectric PDMS/AlN Film for Osteogenesis in Vitro

Bone defect and nonunion are complex diseases which are difficult to treat due to insufficient bone regeneration. Electrical stimulation has attracted attention as a promising strategy to induce and enhance bone regeneration. Self-powered and biocompatible materials have been widely explored and used in biomedical devices, owing to their ability to produce electrical stimulation without an external power source. We aimed to prepare a piezoelectric polydimethylsiloxane (PDMS)/aluminum nitride (AlN) film with excellent biocompatibility and osteoconductive ability for the growth of murine calvarial preosteoblast MC3T3-E1 cells. By applying vibration to stimulate body movement, the PDMS/AlN film demonstrated a current density of 2–6 μA cm^–2, and the generated continuous alternating current (AC) effectively promoted MC3T3-E1 cell growth, viability, and osteoblastic related gene expression (genes runt-related transcription factor 2 [RUNX2], osteocalcin [OCN], alkaline phosphatase [ALP]) and exhibited higher mineralization. Compared to blank plates and nonvibrated PDMS/AlN films, the vibrated PDMS/AlN film showed rapid and superior osteogenic differentiation. The design of the biocompatible and flexible piezoelectric PDMS/AlN film overcame the poor processability, brittleness, and instability of electrical stimulation of traditional electroactive materials, demonstrating great potential in the application of electrical stimulation for bone tissue engineering.

更新日期：2023-06-21

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