<br>基于网络毒理学分析4,4'-磺酰联苯酚致前列腺损伤分子机制研究的新策略,Journal of Applied Toxicology

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基于网络毒理学分析4,4'-磺酰联苯酚致前列腺损伤分子机制研究的新策略
Journal of Applied Toxicology ( IF 2.7 ) Pub Date : 2023-06-20 , DOI: 10.1002/jat.4506
Shujun Huang ₁

Affiliation

该研究旨在探讨4,4'-磺酰二酚（BPS）暴露引起前列腺损伤的潜在分子机制，并提出一种新的研究策略，系统地探索毒物引起的不良健康影响的分子机制。通过利用 ChEMBL、STITCH 和 GeneCards 数据库，总共确定了 208 个与 BPS 暴露和前列腺损伤相关的潜在目标。通过STRING数据库和Cytoscape软件中筛选潜在靶点网络，确定了AKT1、EGFR、MAPK3等21个核心靶点。通过DAVID数据库进行的基因本体论（GO）和京都基因与基因组百科全书（KEGG）通路富集分析表明，BPS在前列腺毒性中的潜在靶点主要富集在癌症信号通路和钙信号通路中。这些发现提示BPS可能通过调节前列腺癌细胞凋亡和增殖、激活炎症信号通路、调节前列腺脂肪细胞和成纤维细胞等方式积极参与前列腺炎症、前列腺增生、前列腺癌等前列腺损伤的发生和发展。该研究为了解BPS引起的前列腺毒性的分子机制提供了理论基础，并为预防和治疗与暴露于含有BPS的塑料制品和某些BPS过度环境相关的前列腺疾病奠定了基础。

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A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4′-sulfonyldiphenol based on network toxicology analysis

The study aimed to investigate the underlying molecular mechanisms of prostate injury induced by 4,4′-sulfonyldiphenol (BPS) exposure and propose a novel research strategy to systematically explore the molecular mechanisms of toxicant-induced adverse health effects. By utilizing the ChEMBL, STITCH, and GeneCards databases, a total of 208 potential targets associated with BPS exposure and prostate injury were identified. Through screening the potential target network in the STRING database and Cytoscape software, we determined 21 core targets including AKT1, EGFR, and MAPK3. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses conducted through the DAVID database illustrated that the potential targets of BPS in prostatic toxicity were primarily enriched in cancer signaling pathways and calcium signaling pathways. These findings suggest that BPS may actively participate in the occurrence and development of prostate inflammation, prostatic hyperplasia, prostate cancer, and other aspects of prostate injury by regulating prostate cancer cell apoptosis and proliferation, activating inflammatory signaling pathways, and modulating prostate adipocytes and fibroblasts. This research provides a theoretical basis for understanding the molecular mechanism of underlying BPS-induced prostatic toxicity and establishes a foundation for the prevention and treatment of prostatic diseases associated with exposure to plastic products containing BPS and certain BPS-overwhelmed environments.

更新日期：2023-06-20

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