仿生抗凝 19F MRI 可视化双层水凝胶管作为高通畅性小直径血管移植物,Small

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仿生抗凝 19F MRI 可视化双层水凝胶管作为高通畅性小直径血管移植物
Small ( IF 13.0 ) Pub Date : 2023-06-20 , DOI: 10.1002/smll.202302621
Shuangyang Li ₁ , Feng Zhao ₂ , Yipeng Tang ₂ , Yiqun Zhang ₁ , Hui Rong ₁ , Lingyuan Liu ₁ , Rui Gao ₃ , Xiang Liu ₁ , Yini Huangfu ₁ , Yunpeng Bai ₂ , Zujian Feng ₃ , Zhigang Guo ₂ , Anjie Dong _{1,

4} , Weiwei Wang ₃ , Deling Kong ₅ , Pingsheng Huang ₃

Affiliation

小直径血管移植物 (SDVG)（ID < 6 mm）的临床通畅性受到限制，壁血栓的形成是这种限制的主要威胁。本文通过优化血管功能与水凝胶分子结构之间的关系，开发了一种基于天然血管基本结构的双层水凝胶管。SDVGs的内层包含两性离子氟化水凝胶，避免血栓炎症诱导的附壁血栓的形成。此外，SDVG 的位置和形态可以通过¹⁹ F/ ¹ H 磁共振成像可视化。SDVGs的外层聚N-丙烯酰甘氨酰胺水凝胶层通过多重可控的分子间氢键相互作用，提供与天然血管相匹配的力学性能，可承受脉动径向压力下的加速疲劳试验3.8亿次循环（相当于体内使用寿命10年）。因此，猪颈动脉移植 9 个月和兔颈动脉移植 3 个月后，SDVG 表现出更高的通畅性 (100%) 和更稳定的形态。因此，这种受生物启发、抗血栓和可视化的 SDVG 为长期通畅产品提供了一种有前景的设计方法，并具有帮助心血管疾病患者的巨大潜力。

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Bioinspired, Anticoagulative, 19F MRI-Visualizable Bilayer Hydrogel Tubes as High Patency Small-Diameter Vascular Grafts

The clinical patency of small-diameter vascular grafts (SDVGs) (ID < 6 mm) is limited, with the formation of mural thrombi being a major threat of this limitation. Herein, a bilayered hydrogel tube based on the essential structure of native blood vessels is developed by optimizing the relation between vascular functions and the molecular structure of hydrogels. The inner layer of the SDVGs comprises a zwitterionic fluorinated hydrogel, avoiding the formation of thromboinflammation-induced mural thrombi. Furthermore, the position and morphology of the SDVGs can be visualized via ¹⁹F/¹H magnetic resonance imaging. The outer poly(N-acryloyl glycinamide) hydrogel layer of SDVGs provides matched mechanical properties with native blood vessels through the multiple and controllable intermolecular hydrogen-bond interactions, which can withstand the accelerated fatigue test under pulsatile radial pressure for 380 million cycles (equal to a service life of 10 years in vivo). Consequently, the SDVGs exhibit higher patency (100%) and more stable morphology following porcine carotid artery transplantation for 9 months and rabbit carotid artery transplantation for 3 months. Therefore, such a bioinspired, antithrombotic, and visualizable SDVG presents a promising design approach for long-term patency products and great potential of helping patients with cardiovascular diseases.

更新日期：2023-06-20

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