调节工程纳米材料与器官屏障的相互作用以增强药物转运,Chemical Society Reviews

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调节工程纳米材料与器官屏障的相互作用以增强药物转运
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2023-06-20 , DOI: 10.1039/d1cs00574j
Vincent Lenders ₁ , Xanthippi Koutsoumpou ₁ , Philana Phan ₂ , Stefaan J Soenen _{1,

3} , Karel Allegaert _{4,

5,

6,

7} , Steven de Vleeschouwer _{8,

9,

10} , Jaan Toelen _{6,

7,

11} , Zongmin Zhao ₂ , Bella B Manshian ₁

Affiliation

Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium.
Department of Hospital Pharmacy, Erasmus MC University Medical Center, CN Rotterdam, 3015, The Netherlands.
Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, B3000 Leuven, Belgium.
Leuven Child and Youth Institute, KU Leuven, 3000 Leuven, Belgium.
Woman and Child, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Department of Pediatrics, University Hospitals Leuven, 3000 Leuven, Belgium.

十多年来，纳米粒子 (NP) 的生物医学用途一直是深入研究的焦点。由于大多数纳米粒子被探索作为载体来改变相关药物的生物分布、药代动力学和生物利用度，因此将这些纳米粒子递送到感兴趣的组织仍然是一个重要的课题。迄今为止，大多数 NP 递送研究都使用肿瘤模型作为其感兴趣的工具，并且系统性施用 NP 的肿瘤靶向的局限性已得到充分研究。近年来，焦点也转移到其他器官，每个器官都面临着自己独特的输送挑战需要克服。在这篇综述中，我们讨论了利用纳米颗粒克服四种主要生物屏障的最新进展，包括肺粘液、胃肠粘液、胎盘屏障和血脑屏障。我们定义了这些生物屏障的具体特性，讨论了与纳米颗粒跨过它们运输相关的挑战，并概述了该领域的最新进展。我们讨论了促进纳米颗粒跨越障碍运输的不同策略的优点和缺点，并重点介绍了一些可以刺激该领域进一步进展的关键发现。

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更新日期：2023-06-20

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