Furan-2-yl Anions as γ-Oxo/Hydroxyl Acyl Anion Equivalents Enabled by Iridium-Catalyzed Chemoselective Reduction,Organic Letters

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Furan-2-yl Anions as γ-Oxo/Hydroxyl Acyl Anion Equivalents Enabled by Iridium-Catalyzed Chemoselective Reduction
Organic Letters ( IF 4.9 ) Pub Date : 2023-06-20 , DOI: 10.1021/acs.orglett.3c01634
Tingting Wang ₁ , Rui Miao ₂ , Renshi Luo _{2,

3} , Jiaxi Xu ₁ , Zhanhui Yang ₁

Affiliation

The last piece of the puzzle: Furan-2-yl anions are first demonstrated as robust γ-oxo and γ-hydroxyl acyl anion equivalents to convert aldehydes and ketones into trifunctionalized dihydroxyl ketones and hydroxyl diones through sequential nucleophilic addition, Achmatowicz rearrangement, and herein freshly established iridium-catalyzed highly selective transfer hydrogenation reduction.

中文翻译：

通过铱催化化学选择性还原实现呋喃-2-基阴离子作为 γ-氧代/羟基酰基阴离子等价物

难题的最后一部分：呋喃-2-基阴离子首先被证明是强大的 γ-氧代和 γ-羟基酰基阴离子等价物，可通过顺序亲核加成、Achmatowicz 重排将醛和酮转化为三官能化二羟基酮和羟基二酮，本文中新建立的铱催化高选择性转移氢化还原反应。

更新日期：2023-06-20

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