Blending Low-Frequency Vibrations and Push–Pull Effects Affords Superior Photoacoustic Imaging Agents,Angewandte Chemie International Edition

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Blending Low-Frequency Vibrations and Push–Pull Effects Affords Superior Photoacoustic Imaging Agents
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-06-19 , DOI: 10.1002/anie.202307797
Le Yu ₁ , Syed Ali Abbas Abedi ₂ , Jeongjin Lee ₃ , Yunjie Xu ₁ , Subin Son ₁ , Weijie Chi _{2,

4} , Mingle Li _{1,

5} , Xiaogang Liu ₂ , Jae Hyung Park _{3,

6} , Jong Seung Kim ₁

Affiliation

In this work, we present a facile but effective approach for engineering photoacoustic imaging (PAI) agents by amplifying intramolecular low-frequency vibrations and enhancing the push-pull effect. As a demonstration of this blended approach, we constructed a PAI agent (BDP1-NEt₂) based on the boron-dipyrromethene (BODIPY) scaffold, which met key requirements of high-quality PAI.

中文翻译：

混合低频振动和推拉效应可提供卓越的光声成像剂

在这项工作中，我们提出了一种简单而有效的方法，通过放大分子内低频振动和增强推拉效应来设计光声成像（PAI）剂。作为这种混合方法的演示，我们构建了一种基于硼二吡咯亚甲基 (BODIPY) 支架的 PAI 试剂 ( BDP1-NEt ₂ )，它满足了高质量 PAI 的关键要求。

更新日期：2023-06-19

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