An Extracellular miRNA-Responsive Artificial Receptor via Dynamic DNA Nano-assembly for Biomarker-Driven Therapy,Angewandte Chemie International Edition

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An Extracellular miRNA-Responsive Artificial Receptor via Dynamic DNA Nano-assembly for Biomarker-Driven Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-06-19 , DOI: 10.1002/anie.202305227
Fang He ₁ , Meixia Wang ₁ , Jieyu Wang ₁ , Hong-Hui Wang ₁ , Zhou Nie ₁

Affiliation

An miRNA-responsive chimeric DNA receptor (miRNA-CDR) as a biomarker-driven therapeutic nanodevice for liver injury repair has been developed. The miRNA-CDR is highly modular, programmable, and versatile, allowing us to customize sense-and-respond programs to diverse user-defined miRNA inputs with a tunable dynamic range, eliciting orthogonal activation of different receptor tyrosine kinases as signaling outputs, which is ultimately used for miRNA biomarker-driven acute liver injury repair.

中文翻译：

通过动态 DNA 纳米组装的细胞外 miRNA 响应人工受体，用于生物标志物驱动的治疗

一种 miRNA 响应性嵌合 DNA 受体 (miRNA-CDR) 作为生物标志物驱动的肝损伤修复治疗纳米器件已被开发出来。miRNA-CDR 具有高度模块化、可编程性和多功能性，使我们能够针对各种用户定义的 miRNA 输入定制感知和响应程序，并具有可调的动态范围，引发不同受体酪氨酸激酶的正交激活作为信号输出，这最终用于miRNA生物标志物驱动的急性肝损伤修复。

更新日期：2023-06-19

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