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Selective Photodynamic Activity of Tetrakis(4-aminophenyl)porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-06-19 , DOI: 10.1002/chem.202301385 Masafumi Okuno 1 , Keita Yamana 1 , Shogo Kawamura 1 , Kotaro Nishimura 1 , Shodai Hino 2 , Riku Kawasaki 1 , Atsushi Ikeda 1
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-06-19 , DOI: 10.1002/chem.202301385 Masafumi Okuno 1 , Keita Yamana 1 , Shogo Kawamura 1 , Kotaro Nishimura 1 , Shodai Hino 2 , Riku Kawasaki 1 , Atsushi Ikeda 1
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The acetylated 5,10,15,20-tetrakis(4-aminophenyl)porphyrin-λ-carrageenan complex had more selective intracellular uptakes and photodynamic activity of cancer cells toward normal cells than the 5,10,15,20-tetrakis(4-aminophenyl)porphyrin-λ-carrageenan complex. Furthermore, the complex improved the photodynamic activity during in vivo experiments owing to its high blood retention.
中文翻译:
具有和不具有乙酰基保护基团的四(4-氨基苯基)卟啉对癌症和正常细胞的选择性光动力活性
乙酰化5,10,15,20-四(4-氨基苯基)卟啉-λ-卡拉胶复合物比5,10,15,20-四(4-氨基苯基)卟啉-λ-卡拉胶复合物。此外,由于其高血液保留,该复合物在体内实验中改善了光动力活性。
更新日期:2023-06-19
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
具有和不具有乙酰基保护基团的四(4-氨基苯基)卟啉对癌症和正常细胞的选择性光动力活性
乙酰化5,10,15,20-四(4-氨基苯基)卟啉-λ-卡拉胶复合物比5,10,15,20-四(4-氨基苯基)卟啉-λ-卡拉胶复合物。此外,由于其高血液保留,该复合物在体内实验中改善了光动力活性。