Selective Photodynamic Activity of Tetrakis(4-aminophenyl)porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells,Chemistry - A European Journal

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Selective Photodynamic Activity of Tetrakis(4-aminophenyl)porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-06-19 , DOI: 10.1002/chem.202301385
Masafumi Okuno ₁ , Keita Yamana ₁ , Shogo Kawamura ₁ , Kotaro Nishimura ₁ , Shodai Hino ₂ , Riku Kawasaki ₁ , Atsushi Ikeda ₁

Affiliation

The acetylated 5,10,15,20-tetrakis(4-aminophenyl)porphyrin-λ-carrageenan complex had more selective intracellular uptakes and photodynamic activity of cancer cells toward normal cells than the 5,10,15,20-tetrakis(4-aminophenyl)porphyrin-λ-carrageenan complex. Furthermore, the complex improved the photodynamic activity during in vivo experiments owing to its high blood retention.

中文翻译：

具有和不具有乙酰基保护基团的四(4-氨基苯基)卟啉对癌症和正常细胞的选择性光动力活性

乙酰化5,10,15,20-四(4-氨基苯基)卟啉-λ-卡拉胶复合物比5,10,15,20-四(4-氨基苯基）卟啉-λ-卡拉胶复合物。此外，由于其高血液保留，该复合物在体内实验中改善了光动力活性。

更新日期：2023-06-19

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